结构变异与物种形成:多重过程在起作用

IF 6.9 2区 生物学 Q1 CELL BIOLOGY
Emma L Berdan, Thomas G Aubier, Salvatore Cozzolino, Rui Faria, Jeffrey L Feder, Mabel D Giménez, Mathieu Joron, Jeremy B Searle, Claire Mérot
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引用次数: 0

摘要

对物种变异基因组结构的研究越来越多地揭示了结构变异(SV)的重要性,这种变异会影响核苷酸序列的存在、丰度、位置和/或方向。SVs 包括融合/裂解、倒位和易位等大型染色体重排,以及重复、插入和缺失(CNVs)等较小的变异。尽管我们有大量证据表明 SV 在物种演化过程中扮演着重要角色,但其基本机制却因 SV 的类型、长度以及生态、人口和历史背景的不同而各异。在探讨最新的测序方法如何揭示 SVs 的普遍性和多样性之前,我们回顾了经典过程的预测和经验证据,如减数分裂畸变导致的劣势和重组抑制的耦合效应。我们讨论了SVs的具体特性及其对整个基因组的影响,强调在SVs与物种演化的关系中,有多个过程在起作用,而且可能是相互作用的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structural Variants and Speciation: Multiple Processes at Play.

Research on the genomic architecture of speciation has increasingly revealed the importance of structural variants (SVs) that affect the presence, abundance, position, and/or direction of a nucleotide sequence. SVs include large chromosomal rearrangements such as fusion/fissions and inversions and translocations, as well as smaller variants such as duplications, insertions, and deletions (CNVs). Although we have ample evidence that SVs play a key role in speciation, the underlying mechanisms differ depending on the type and length of the SV, as well as the ecological, demographic, and historical context. We review predictions and empirical evidence for classic processes such as underdominance due to meiotic aberrations and the coupling effect of recombination suppression before exploring how recent sequencing methodologies illuminate the prevalence and diversity of SVs. We discuss specific properties of SVs and their impact throughout the genome, highlighting that multiple processes are at play, and possibly interacting, in the relationship between SVs and speciation.

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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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