一例服用二肽基肽酶 4 抑制剂后出现大疱性丘疹和肾病的病例。

IF 1 Q4 UROLOGY & NEPHROLOGY

CEN Case Reports Pub Date : 2024-08-01 Epub Date: 2023-12-06 DOI:10.1007/s13730-023-00835-1

Atsuhiko Suenaga, Naoki Sawa, Yuki Oba, Daisuke Ikuma, Akinari Sekine, Masayuki Yamanouchi, Eiko Hasegawa, Hiroki Mizuno, Tatsuya Suwabe, Nobukazu Hayashi, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Motoaki Miyazono, Yutaka Yamaguchi, Yoshifumi Ubara

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引用次数: 0

摘要

一名 62 岁的 2 型糖尿病患者因估计肾小球滤过率在 10 年内从 72 毫升/分钟/1.73 平方米降至 17.5 毫升/分钟/1.73 平方米，并出现大面积牛皮癣而入院。他服用二肽基肽酶（DPP）-4 抑制剂 10 年，血红蛋白 A1c 水平一直保持在 6.0-7.0% 之间。皮肤活检显示为典型的大疱性丘疹，肾活检显示为肾小管间质性肾炎，伴有嗜酸性粒细胞浸润和肾小球内皮细胞增生。停用 DPP-4 抑制剂后，皮损有所改善，肾功能衰退减缓。本病例表明，DPP-4 抑制剂不仅可导致皮肤病变，还可导致肾脏疾病。

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A case of bullous pemphigoid and renal disease after dipeptidyl peptidase 4 inhibitor administration.

A 62-year-old man with type 2 diabetes was admitted because of a decrease in estimated glomerular filtration rate from 72 to 17.5 mL/min/1.73 m² in 10 years and development of widespread bullous skin lesions. His hemoglobin A1c level had been maintained at 6.0-7.0% for 10 years with a dipeptidyl peptidase (DPP)-4 inhibitor. Skin biopsy showed typical bullous pemphigoid, and kidney biopsy showed tubulointerstitial nephritis with eosinophilic infiltration and glomerular endothelial cell proliferation. After discontinuing the DPP-4 inhibitor, skin lesions improved, and renal decline slowed. This case indicates that DPP-4 inhibitors can cause not only skin lesions but also renal disease.

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来源期刊

CEN Case Reports UROLOGY & NEPHROLOGY-

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Clinical and Experimental Nephrology (CEN) Case Reports is a peer-reviewed online-only journal, officially published biannually by the Japanese Society of Nephrology (JSN). The journal publishes original case reports in nephrology and related areas. The purpose of CEN Case Reports is to provide clinicians and researchers with a forum in which to disseminate their personal experience to a wide readership and to review interesting cases encountered by colleagues all over the world, from whom contributions are welcomed.