从贯叶连翘枝和叶中提取的具有抗血管生成活性的三种新酰基间苯三酚。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-12-05 DOI:10.1080/14786419.2023.2278176

Hao Zhang, Kunling Wang, Fan Chen

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引用次数: 0

摘要

从贯叶连珠(Hypericum perforatum L.)的枝叶中分离到3个新的酰基间苯三酚，命名为hyperpersions A-C(1-3)，并分离到3个已知化合物，分别鉴定为elegaphenone(4)、2,6-二羟基-3,4-二甲基苯甲酸甲酯(5)和2,3-亚甲基二氧山酮(6)。通过紫外光谱(UV)、红外光谱(IR)、质谱(HR-ESI-MS)、核磁共振(NMR)等方法对化合物的结构进行了表征。研究了它们对HUVECs的抗血管生成活性。化合物3对HUVECs的IC50值为2.39±0.21 μM，强于vatalanib，其余化合物均具有中等抗血管生成活性。

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Hyperipersions A-C, three new acylphloroglucinols from the branches and leaves of Hypericum perforatum L. with antiangiogenic activities.

Three new acylphloroglucinols were isolated from the branches and leaves of Hypericum perforatum L., named as hyperipersions A-C (1-3), together with three known compounds which were identified as elegaphenone (4), 2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester (5) and 2,3-methylenedioxyxanthone (6), respectively. The structures of isolated compounds were determined by UV, IR, HR-ESI-MS, NMR analysis. Their antiangiogenic activities were studied against HUVECs. The IC₅₀ value of compound 3 was 2.39 ± 0.21 μM against HUVECs, which was stronger than vatalanib, and other compounds had moderate antiangiogenic activity.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.