在严重慢性自发性荨麻疹中，超过高亲和力IgE受体的肥大细胞释放组胺的机制。

IF 3.3 4区医学 Q3 IMMUNOLOGY

Immunology letters Pub Date : 2023-11-30 DOI:10.1016/j.imlet.2023.11.008

Riccardo Asero

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引用次数: 0

摘要

越来越多的证据表明，在一部分严重慢性荨麻疹(CSU)患者中，肥大细胞通过绕过高亲和力IgE受体的机制被激活。这也许可以解释为什么一些患者对抗ige治疗(omalizumab)完全没有反应。本文综述了迄今为止在CSU患者中描述的导致肥大细胞释放组胺的致病机制。包括凝血级联的激活、补体系统的激活、MRGPRX2受体的激活、血小板活化因子的恶性循环等。文章提出了一些可能的解释，发生在这一特定的病人的临床事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanisms of histamine release from mast cells beyond the high affinity IgE receptor in severe chronic spontaneous urticaria

There is growing evidence suggesting that in a subset of patients with severe chronic urticaria [CSU] mast cells are activated via mechanisms that bypass the high affinity IgE receptor. This might explain why some patients do not respond at all to anti-IgE therapy [omalizumab]. The present article reviews the pathogenic mechanisms able to lead to histamine release from mast cells described so far in patients with CSU. These include the activation of the coagulation cascade, the activation of the complement system, the activation of the MRGPRX2 receptor, and the platelet activating factor vicious circle. The article suggests some possible interpretations for the clinical events occurring in this specific subset of patients.

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来源期刊

Immunology letters 医学-免疫学

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

44 days

期刊介绍： Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.