Guillaume Costalat, Frederic Lemaitre, Sandra Ramos, Gillian M C Renshaw
{"title":"间歇性常压缺氧改变肥胖个体的底物分配和肌肉氧合:对脂肪燃烧的影响。","authors":"Guillaume Costalat, Frederic Lemaitre, Sandra Ramos, Gillian M C Renshaw","doi":"10.1152/ajpregu.00153.2023","DOIUrl":null,"url":null,"abstract":"<p><p>This single-blind, crossover study aimed to measure and evaluate the short-term metabolic responses to continuous and intermittent hypoxic patterns in individuals with obesity. Indirect calorimetry was used to quantify changes in resting metabolic rate (RMR), carbohydrate (CHO<sub>ox</sub>, %CHO), and fat oxidation (FAT<sub>ox</sub>, %FAT) in nine individuals with obesity pre and post: <i>1</i>) breathing normoxic air [normoxic sham control (NS-control)], <i>2</i>) breathing continuous hypoxia (CH), or <i>3</i>) breathing intermittent hypoxia (IH). A mean peripheral oxygen saturation ([Formula: see text]) of 80-85% was achieved over a total of 45 min of hypoxia. Throughout each intervention, pulmonary gas exchanges, oxygen consumption (V̇o<sub>2</sub>) carbon dioxide production (V̇co<sub>2</sub>), and deoxyhemoglobin concentration (Δ[HHb]) in the vastus lateralis were measured. Both RMR and CHO<sub>ox</sub> measured pre- and postinterventions were unchanged following each treatment: NS-control, CH, or IH (all <i>P</i> > 0.05). Conversely, a significant increase in FAT<sub>ox</sub> was evident between pre- and post-IH (+44%, <i>P</i> = 0.048). Although the mean Δ[HHb] values significantly increased during both IH and CH (<i>P</i> < 0.05), the greatest zenith of Δ[HHb] was achieved in IH compared with CH (<i>P</i> = 0.002). Furthermore, there was a positive correlation between Δ[HHb] and the shift in FAT<sub>ox</sub> measured pre- and postintervention. It is suggested that during IH, the increased bouts of muscle hypoxia, revealed by elevated Δ[HHb], coupled with cyclic periods of excess posthypoxia oxygen consumption (EPHOC, inherent to the intermittent pattern) played a significant role in driving the increase in FAT<sub>ox</sub> post-IH.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. 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Indirect calorimetry was used to quantify changes in resting metabolic rate (RMR), carbohydrate (CHO<sub>ox</sub>, %CHO), and fat oxidation (FAT<sub>ox</sub>, %FAT) in nine individuals with obesity pre and post: <i>1</i>) breathing normoxic air [normoxic sham control (NS-control)], <i>2</i>) breathing continuous hypoxia (CH), or <i>3</i>) breathing intermittent hypoxia (IH). A mean peripheral oxygen saturation ([Formula: see text]) of 80-85% was achieved over a total of 45 min of hypoxia. Throughout each intervention, pulmonary gas exchanges, oxygen consumption (V̇o<sub>2</sub>) carbon dioxide production (V̇co<sub>2</sub>), and deoxyhemoglobin concentration (Δ[HHb]) in the vastus lateralis were measured. Both RMR and CHO<sub>ox</sub> measured pre- and postinterventions were unchanged following each treatment: NS-control, CH, or IH (all <i>P</i> > 0.05). Conversely, a significant increase in FAT<sub>ox</sub> was evident between pre- and post-IH (+44%, <i>P</i> = 0.048). Although the mean Δ[HHb] values significantly increased during both IH and CH (<i>P</i> < 0.05), the greatest zenith of Δ[HHb] was achieved in IH compared with CH (<i>P</i> = 0.002). Furthermore, there was a positive correlation between Δ[HHb] and the shift in FAT<sub>ox</sub> measured pre- and postintervention. It is suggested that during IH, the increased bouts of muscle hypoxia, revealed by elevated Δ[HHb], coupled with cyclic periods of excess posthypoxia oxygen consumption (EPHOC, inherent to the intermittent pattern) played a significant role in driving the increase in FAT<sub>ox</sub> post-IH.</p>\",\"PeriodicalId\":7630,\"journal\":{\"name\":\"American journal of physiology. 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Intermittent normobaric hypoxia alters substrate partitioning and muscle oxygenation in individuals with obesity: implications for fat burning.
This single-blind, crossover study aimed to measure and evaluate the short-term metabolic responses to continuous and intermittent hypoxic patterns in individuals with obesity. Indirect calorimetry was used to quantify changes in resting metabolic rate (RMR), carbohydrate (CHOox, %CHO), and fat oxidation (FATox, %FAT) in nine individuals with obesity pre and post: 1) breathing normoxic air [normoxic sham control (NS-control)], 2) breathing continuous hypoxia (CH), or 3) breathing intermittent hypoxia (IH). A mean peripheral oxygen saturation ([Formula: see text]) of 80-85% was achieved over a total of 45 min of hypoxia. Throughout each intervention, pulmonary gas exchanges, oxygen consumption (V̇o2) carbon dioxide production (V̇co2), and deoxyhemoglobin concentration (Δ[HHb]) in the vastus lateralis were measured. Both RMR and CHOox measured pre- and postinterventions were unchanged following each treatment: NS-control, CH, or IH (all P > 0.05). Conversely, a significant increase in FATox was evident between pre- and post-IH (+44%, P = 0.048). Although the mean Δ[HHb] values significantly increased during both IH and CH (P < 0.05), the greatest zenith of Δ[HHb] was achieved in IH compared with CH (P = 0.002). Furthermore, there was a positive correlation between Δ[HHb] and the shift in FATox measured pre- and postintervention. It is suggested that during IH, the increased bouts of muscle hypoxia, revealed by elevated Δ[HHb], coupled with cyclic periods of excess posthypoxia oxygen consumption (EPHOC, inherent to the intermittent pattern) played a significant role in driving the increase in FATox post-IH.
期刊介绍:
The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.