间歇性常压缺氧改变肥胖个体的底物分配和肌肉氧合:对脂肪燃烧的影响。

IF 2.2 3区 医学 Q3 PHYSIOLOGY
Guillaume Costalat, Frederic Lemaitre, Sandra Ramos, Gillian M C Renshaw
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引用次数: 0

摘要

这项单盲交叉研究旨在测量和评估肥胖患者对持续和间歇性缺氧模式的短期代谢反应。采用间接量热法量化9例肥胖患者静息代谢率(RMR)、碳水化合物(chox, %CHO)和脂肪氧化(FATox, % fat)在以下前后的变化:(i)呼吸常压空气[常压假对照(NS-control)];(ii)呼吸持续缺氧(CH);或(iii)间歇性缺氧(IH)。在45分钟的缺氧时间内,平均外周氧饱和度(SpO2)达到80-85%。在每次干预过程中,测量肺气体交换——耗氧量()、二氧化碳产生()和股外侧肌脱氧血红蛋白浓度([hbb])。每次治疗后,干预前和干预后的RMR和chox测量结果都没有变化:CH;或IH(均p > 0.05)。相反,在ih前后,FATox显著增加(+44%,p = 0.048)。虽然平均[hbb]值在IH和CH期间显著增加(p),但与CH相比,IH达到了[hbb]的最大顶点(p = 0.002)。此外,干预前后测得的FATox变化与∆[hbb]呈正相关。这表明,在IH期间,肌肉缺氧次数的增加(表现为升高的∆[hbb]),加上缺氧后过量氧气消耗的循环周期(EPHOC,固有的间歇性模式)在推动IH后FATox的增加中发挥了重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intermittent normobaric hypoxia alters substrate partitioning and muscle oxygenation in individuals with obesity: implications for fat burning.

This single-blind, crossover study aimed to measure and evaluate the short-term metabolic responses to continuous and intermittent hypoxic patterns in individuals with obesity. Indirect calorimetry was used to quantify changes in resting metabolic rate (RMR), carbohydrate (CHOox, %CHO), and fat oxidation (FATox, %FAT) in nine individuals with obesity pre and post: 1) breathing normoxic air [normoxic sham control (NS-control)], 2) breathing continuous hypoxia (CH), or 3) breathing intermittent hypoxia (IH). A mean peripheral oxygen saturation ([Formula: see text]) of 80-85% was achieved over a total of 45 min of hypoxia. Throughout each intervention, pulmonary gas exchanges, oxygen consumption (V̇o2) carbon dioxide production (V̇co2), and deoxyhemoglobin concentration (Δ[HHb]) in the vastus lateralis were measured. Both RMR and CHOox measured pre- and postinterventions were unchanged following each treatment: NS-control, CH, or IH (all P > 0.05). Conversely, a significant increase in FATox was evident between pre- and post-IH (+44%, P = 0.048). Although the mean Δ[HHb] values significantly increased during both IH and CH (P < 0.05), the greatest zenith of Δ[HHb] was achieved in IH compared with CH (P = 0.002). Furthermore, there was a positive correlation between Δ[HHb] and the shift in FATox measured pre- and postintervention. It is suggested that during IH, the increased bouts of muscle hypoxia, revealed by elevated Δ[HHb], coupled with cyclic periods of excess posthypoxia oxygen consumption (EPHOC, inherent to the intermittent pattern) played a significant role in driving the increase in FATox post-IH.

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来源期刊
CiteScore
5.30
自引率
3.60%
发文量
145
审稿时长
2 months
期刊介绍: The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.
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