表面活性剂作为药物载体。

IF 2.9 3区医学 Q1 PEDIATRICS

Seminars in Fetal & Neonatal Medicine Pub Date : 2023-12-01 DOI:10.1016/j.siny.2023.101499

Arun Sett , Charles C. Roehr , Brett J. Manley

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引用次数: 1

摘要

使用表面活性剂载体的药物递送具有通过将治疗剂直接递送到呼吸系统来防止全身副作用的潜力。表面活性剂固有的化学性质使其易于分布在整个呼吸系统。由表面活性剂输送的治疗剂主要能带来额外的益处，但也有可能改善表面活性剂的功能。至关重要的是，附加剂不干扰表面活性剂的固有表面张力降低功能。需要通过台式、转化和人体试验进行系统评估，才能将这种潜在的技术转化为临床实践。

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Surfactant as a drug carrier

Drug delivery using a surfactant vehicle has the potential to prevent systemic side effects by delivering therapeutic agents directly to the respiratory system. The inherent chemical properties of surfactant allows it to readily distribute throughout the respiratory system. Therapeutic agents delivered by surfactant can primarily confer additional benefits but have potential to improve surfactant function. It is critically important that additional agents do not interefere with the innate surface tension lowering function of surfactant. Systemic evaluation through benchtop, translational and human trials are required to translate this potential technique into clinical practice.

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来源期刊

Seminars in Fetal & Neonatal Medicine 医学-小儿科

CiteScore

6.40

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Fetal & Neonatal Medicine (formerly Seminars in Neonatology) is a bi-monthly journal which publishes topic-based issues, including current ''Hot Topics'' on the latest advances in fetal and neonatal medicine. The Journal is of interest to obstetricians and maternal-fetal medicine specialists. The Journal commissions review-based content covering current clinical opinion on the care and treatment of the pregnant patient and the neonate and draws on the necessary specialist knowledge, including that of the pediatric pulmonologist, the pediatric infectious disease specialist, the surgeon, as well as the general pediatrician and obstetrician. Each topic-based issue is edited by an authority in their field and contains 8-10 articles. Seminars in Fetal & Neonatal Medicine provides: • Coverage of major developments in neonatal care; • Value to practising neonatologists, consultant and trainee pediatricians, obstetricians, midwives and fetal medicine specialists wishing to extend their knowledge in this field; • Up-to-date information in an attractive and relevant format.