标准治疗后种植体周围粘膜炎的解决:一项前瞻性裂口研究。

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Mia Rakic, Zoran Tatic, Sandro Radovanovic, Aleksandra Petkovic-Curcin, Danilo Vojvodic, Alberto Monje
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引用次数: 0

摘要

背景:种植体周围粘膜炎(PIM)是种植体周围炎的病理前兆,但其转化为种植体周围炎的模式尚不清楚,临床上诊断复杂,而现有的方案均不能完全解决疾病。本研究的目的是在临床和生物标志物水平上评估PIM对标准抗感染机械治疗(AIMT)的反应性,并评估骨标志物作为替代终点和预测因子的诊断能力。方法:纳入系统健康门诊患者,其中一个种植体表现出软组织内炎症的临床症状(PIM),另一个健康对照(HC)种植体位于非邻近位置。基线和机械治疗后6个月收集临床参数和种植体周围沟液样本,评估RANKL、OPG和IGFBP2水平。使用机器学习算法进行PIM聚类。结果:38例患者符合纳入标准。治疗导致所有临床和生物学指标降低,但与HC相比,各自的值仍显着较高。临床检查显示,在6个月的随访中,30%的疾病消退,而43%的患者骨吸收不活跃。OPG对治疗结果有积极的预后价值,而基于主动骨吸收的聚类在治疗效果方面没有差异。结论:AIMT能有效降低PIM的临床及生物学指标,但临床完全缓解的病例仅占30%。大约三分之一的PIM患者表现出活跃的骨吸收低于临床可检测性,这与疾病进展和治疗反应性差无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resolution of peri-implant mucositis following standard treatment: A prospective split-mouth study

Background

Peri-implant mucositis (PIM) is a pathological precursor of peri-implantitis, but its pattern of conversion to peri-implantitis is unclear and complicated to diagnose clinically, while none of the available protocols yield complete disease resolution. The aim of this study was the evaluation of PIM responsiveness to standard anti-infective mechanical treatment (AIMT) at clinical and biomarker levels, and estimation of the diagnostic capacity of bone markers as surrogate endpoints and predictors.

Methods

Systemically healthy outpatients presenting one implant exhibiting clinical signs of inflammation confined within the soft tissue (PIM) and one healthy control (HC) implant at a non-adjacent position were included. Clinical parameters and peri-implant crevicular fluid samples were collected baseline and 6 months following mechanical therapy, to assess the levels of RANKL, OPG, and IGFBP2. PIM clustering was performed using machine learning algorithms.

Results

Overall, 38 patients met the inclusion criteria. Therapy resulted in the reduction of all clinical and biological indicators, but respective values remained significantly higher compared to HC. Clinical examination noted 30% disease resolution at the 6-month follow-up, while 43% showed no active bone resorption. OPG showed positive prognostic value for treatment outcome, while the clustering based on active bone resorption did not differ in terms of therapeutic effectiveness.

Conclusion

AIMT is effective in reducing the clinical and biological indicators of PIM, but complete clinical resolution was achieved in only 30% of the cases. Around one third of PIM patients exhibited active bone resorption bellow clinical detectability that was not associated with disease progression and poor treatment responsiveness.

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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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