润滑大肠癌药物治疗的车轮:天然多酚的作用。

IF 4.6 3区 医学 Q1 NUTRITION & DIETETICS
Current Nutrition Reports Pub Date : 2023-12-01 Epub Date: 2023-12-02 DOI:10.1007/s13668-023-00512-w
Chengu Niu, Jing Zhang, Patrick Okolo
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引用次数: 0

摘要

综述目的:本综述以临床前研究为基础,主要目的是总结天然多酚抗结直肠癌的药理和生化证据,并指出未来需要研究的领域。最近的发现:一般来说,结直肠癌是一种潜在的可预防和可治愈的癌症,起源于结肠内壁的良性癌前息肉。结直肠癌是第三大最常见的癌症,其终生风险约为4%至5%。遗传背景和环境因素在结直肠癌的发病中起主要作用。从理论上讲,结直肠癌的多步骤发生过程为结直肠癌的抗肿瘤药物治疗提供了充足的时间。慢性结肠炎症、氧化应激和肠道微生物群失衡已被发现通过在肠道环境中产生基因毒性应激来产生基因突变和表观遗传修饰,从而增加结直肠癌发展的风险。目前,许多天然多酚在临床前研究中,特别是在结直肠癌细胞系中显示出抗肿瘤的特性。在这篇综述中,简要概述了目前关于结直肠癌病因学和流行病学的文献。我们强调从体外和体内研究中发现的天然多酚在结直肠癌中的作用。人体试验数据的缺乏削弱了天然多酚作为抗结直肠癌药物的临床应用,这应该在未来进行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Greasing the Wheels of Pharmacotherapy for Colorectal Cancer: the Role of Natural Polyphenols.

Purpose of review: The main purpose of this review, mainly based on preclinical studies, is to summarize the pharmacological and biochemical evidence regarding natural polyphenols against colorectal cancer and highlight areas that require future research.

Recent findings: Typically, colorectal cancer is a potentially preventable and curable cancer arising from benign precancerous polyps found in the colon's inner lining. Colorectal cancer is the third most common cancer, with a lifetime risk of approximately 4 to 5%. Genetic background and environmental factors play major roles in the pathogenesis of colorectal cancer. Theoretically, a multistep process of colorectal carcinogenesis provides enough time for anti-tumor pharmacotherapy of colorectal cancer. Chronic colonic inflammation, oxidative stress, and gut microbiota imbalance have been found to increase the risk for colorectal cancer development by creating genotoxic stress within the intestinal environment to generate genetic mutations and epigenetic modifications. Currently, numerous natural polyphenols have shown anti-tumor properties against colorectal cancer in preclinical research, especially in colorectal cancer cell lines. In this review, the current literature regarding the etiology and epidemiology of colorectal cancer is briefly outlined. We highlight the findings of natural polyphenols in colorectal cancer from in vitro and in vivo studies. The scarcity of human trials data undermines the clinical use of natural polyphenols as anti-colorectal cancer agents, which should be undertaken in the future.

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来源期刊
Current Nutrition Reports
Current Nutrition Reports Agricultural and Biological Sciences-Food Science
CiteScore
7.70
自引率
2.00%
发文量
59
期刊介绍: This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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