Mohamad A. Rosli MS (Plastic Surgery) , Nur A. Mohd Nasir PhD , Mohd Z. Mustafa PhD , Muhammad A. Othman MD , Zaidi Zakaria MMed (Surgery) , Ahmad S. Halim FCCP
{"title":"无刺蜂(Kelulut)蜂蜜与常规凝胶敷料在糖尿病创面制备中的有效性:一项随机对照试验","authors":"Mohamad A. Rosli MS (Plastic Surgery) , Nur A. Mohd Nasir PhD , Mohd Z. Mustafa PhD , Muhammad A. Othman MD , Zaidi Zakaria MMed (Surgery) , Ahmad S. Halim FCCP","doi":"10.1016/j.jtumed.2023.11.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Kelulut honey contains trehalulose and has high antioxidant content, such as phenolic and flavonoid substances, which can promote wound healing. This study evaluated the effectiveness of Kelulut honey in diabetic wound healing compared to a commercially available conventional gel dressing (Intrasite gel).</p></div><div><h3>Methods</h3><p>A prospective, randomized, single-blinded control trial was performed on eligible diabetic patients with full-thickness cavity wounds. Patients’ demographics, size and site of wounds, and baseline routine blood investigations were recorded. The wounds were dressed every other day with Kelulut honey for the intervention group or gel for the control group. The wound size reduction and granulation tissue formation percentage were calculated every 6 days for 1 month.</p></div><div><h3>Results</h3><p>Seventy-one patients were randomized. After 30 days of follow-up, 62 participants were available for analysis: 30 from the control group and 32 from the treatment group. The control group had increased granulation tissue at baseline and more wounds on the lower limb and posterior trunk. Both groups showed an increasing mean and median percentage of wound epithelialization and granulation tissue over time, with significantly higher values at every timepoint in the honey group (p < 0.05). However, repeated measures analysis of variance and analysis of covariance revealed no significant interaction effect between the different treatments and time, with F (2.02, 121.28) = 0.88, p = 0.417 and F (1.60, 93.95) = 0.79, p = 0.431, respectively.</p></div><div><h3>Conclusion</h3><p>This study revealed that Kelulut honey was comparable to and as effective as the conventional gel in treating diabetic wounds in terms of promoting epithelialization and granulation tissue formation.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223002159/pdfft?md5=82e0c549471ba64878c9ebee4c486ac1&pid=1-s2.0-S1658361223002159-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Effectiveness of stingless bee (Kelulut) honey versus conventional gel dressing in diabetic wound bed preparation: A randomized controlled trial\",\"authors\":\"Mohamad A. Rosli MS (Plastic Surgery) , Nur A. Mohd Nasir PhD , Mohd Z. Mustafa PhD , Muhammad A. Othman MD , Zaidi Zakaria MMed (Surgery) , Ahmad S. Halim FCCP\",\"doi\":\"10.1016/j.jtumed.2023.11.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>Kelulut honey contains trehalulose and has high antioxidant content, such as phenolic and flavonoid substances, which can promote wound healing. This study evaluated the effectiveness of Kelulut honey in diabetic wound healing compared to a commercially available conventional gel dressing (Intrasite gel).</p></div><div><h3>Methods</h3><p>A prospective, randomized, single-blinded control trial was performed on eligible diabetic patients with full-thickness cavity wounds. Patients’ demographics, size and site of wounds, and baseline routine blood investigations were recorded. The wounds were dressed every other day with Kelulut honey for the intervention group or gel for the control group. The wound size reduction and granulation tissue formation percentage were calculated every 6 days for 1 month.</p></div><div><h3>Results</h3><p>Seventy-one patients were randomized. After 30 days of follow-up, 62 participants were available for analysis: 30 from the control group and 32 from the treatment group. The control group had increased granulation tissue at baseline and more wounds on the lower limb and posterior trunk. Both groups showed an increasing mean and median percentage of wound epithelialization and granulation tissue over time, with significantly higher values at every timepoint in the honey group (p < 0.05). However, repeated measures analysis of variance and analysis of covariance revealed no significant interaction effect between the different treatments and time, with F (2.02, 121.28) = 0.88, p = 0.417 and F (1.60, 93.95) = 0.79, p = 0.431, respectively.</p></div><div><h3>Conclusion</h3><p>This study revealed that Kelulut honey was comparable to and as effective as the conventional gel in treating diabetic wounds in terms of promoting epithelialization and granulation tissue formation.</p></div>\",\"PeriodicalId\":46806,\"journal\":{\"name\":\"Journal of Taibah University Medical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2023-11-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1658361223002159/pdfft?md5=82e0c549471ba64878c9ebee4c486ac1&pid=1-s2.0-S1658361223002159-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Taibah University Medical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1658361223002159\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Taibah University Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1658361223002159","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
目的:kelulut蜂蜜含有海藻糖,具有较高的抗氧化含量,如酚类和类黄酮类物质,可以促进伤口愈合。本研究评估了Kelulut蜂蜜在糖尿病伤口愈合中的有效性,并与市售的常规凝胶敷料(Intrasite凝胶)进行了比较。方法采用前瞻性、随机、单盲对照试验对符合条件的糖尿病全层腔创面患者进行研究。记录患者的人口统计学、伤口大小和部位以及基线血常规调查。干预组每隔一天用克鲁鲁特蜂蜜包扎伤口,对照组用凝胶包扎伤口。每6天计算创面缩小率和肉芽组织形成率,持续1个月。结果71例患者被随机化。经过30天的随访,62名参与者可用于分析:30名来自对照组,32名来自治疗组。对照组在基线时肉芽组织增多,下肢和后躯干伤口增多。随着时间的推移,两组伤口上皮化和肉芽组织的平均和中位数百分比都有所增加,蜂蜜组在每个时间点的数值都显著高于对照组(p <0.05)。然而,重复测量方差分析和协方差分析显示,不同处理与时间之间无显著交互作用,F (2.02, 121.28) = 0.88, p = 0.417; F (1.60, 93.95) = 0.79, p = 0.431。结论在促进糖尿病创面上皮化和肉芽组织形成方面,克鲁鲁特蜂蜜与常规凝胶具有相当的疗效。
Effectiveness of stingless bee (Kelulut) honey versus conventional gel dressing in diabetic wound bed preparation: A randomized controlled trial
Purpose
Kelulut honey contains trehalulose and has high antioxidant content, such as phenolic and flavonoid substances, which can promote wound healing. This study evaluated the effectiveness of Kelulut honey in diabetic wound healing compared to a commercially available conventional gel dressing (Intrasite gel).
Methods
A prospective, randomized, single-blinded control trial was performed on eligible diabetic patients with full-thickness cavity wounds. Patients’ demographics, size and site of wounds, and baseline routine blood investigations were recorded. The wounds were dressed every other day with Kelulut honey for the intervention group or gel for the control group. The wound size reduction and granulation tissue formation percentage were calculated every 6 days for 1 month.
Results
Seventy-one patients were randomized. After 30 days of follow-up, 62 participants were available for analysis: 30 from the control group and 32 from the treatment group. The control group had increased granulation tissue at baseline and more wounds on the lower limb and posterior trunk. Both groups showed an increasing mean and median percentage of wound epithelialization and granulation tissue over time, with significantly higher values at every timepoint in the honey group (p < 0.05). However, repeated measures analysis of variance and analysis of covariance revealed no significant interaction effect between the different treatments and time, with F (2.02, 121.28) = 0.88, p = 0.417 and F (1.60, 93.95) = 0.79, p = 0.431, respectively.
Conclusion
This study revealed that Kelulut honey was comparable to and as effective as the conventional gel in treating diabetic wounds in terms of promoting epithelialization and granulation tissue formation.