评估镁和锌在临床疾病中的作用。

David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Armando Valenzuela Peraza, Ernestina Hernández Garcia, Gerardo Barragán Mejía, Hugo Juarez Olguin
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引用次数: 0

摘要

镁(Mg2+)和锌(Zn2+)与磷酸盐离子相互作用的能力和便利赋予它们必需微量元素的特征。微量元素对所有已知生物细胞的基本核酸化学是极其必要的。超过300种酶需要锌和镁离子才能发挥催化作用,包括所有参与ATP合成的酶。此外,使用其他核苷酸合成DNA和RNA的异构体酶、氧化还原酶、裂解酶、转移酶、连接酶和水解酶等酶也需要镁和锌。这些核苷酸可能引发氧化损伤或对抗自由基的重要变化。以同样的方式,核苷酸可能在退行性疾病的病理生理学中发挥重要作用,包括在一些临床疾病中,血管危险因素、氧化应激和炎症会破坏患者的体内平衡。事实上,锌和镁水平的降低可能导致抗氧化酶的不足,因此,作为诱导氧化应激导致细胞或组织功能障碍的重要因素。因此,锌或镁酶抑制剂的开发可能是治疗一些人类疾病的新机会。因此,本研究的目的是评估锌和镁对人体健康的临床益处及其对某些临床疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of the Roles of Magnesium and Zinc in Clinical Disorders.

The ability and facility of magnesium (Mg2+) and zinc (Zn2+) to interact with phosphate ions confer them the characteristics of essential trace elements. Trace elements are extremely necessary for the basic nucleic acid chemistry of cells of all known living organisms. More than 300 enzymes require zinc and magnesium ions for their catalytic actions, including all the enzymes involved in the synthesis of ATP. In addition, enzymes such as isomerases, oxidoreductases, lyases, transferases, ligases and hydrolases that use other nucleotides to synthesize DNA and RNA require magnesium and zinc. These nucleotides may trigger oxidative damage or important changes against free radicals. In the same way, nucleotides may play an important role in the pathophysiology of degenerative diseases, including in some clinical disorders, where vascular risk factors, oxidative stress and inflammation work to destabilize the patients` homeostatic equilibrium. Indeed, reduced levels of zinc and magnesium may lead to inadequate amount of antioxidant enzymes, and thus, acts as an important contributing factor for the induction of oxidative stress leading to cellular or tissue dysfunction. Hence, the development of zinc or magnesium enzyme inhibitors could be a novel opportunity for the treatment of some human disorders. Therefore, the objective of the present work was to assess the clinical benefits of zinc and magnesium in human health and their effects in some clinical disorders.

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