Hamza Elbouny, Brahim Ouahzizi, Oussama Bekkouch, Amal Bennani, Souliman Amrani, Mhamed Ramchoun, Khalid Sellam, Chakib Alem
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At the end of the experiment, lipid levels and paraoxonase arylesterase activity were measured, and aorta histology was studied.</p><p><strong>Results: </strong>Our findings revealed that there was an important elevation of blood lipids in the HFD group along with a significant decrease in paraoxonase arylesterase activity (-40.06%). Moreover, the consumption of fat altered the histology of aorta by thickening the intima media and forming atherosclerotic lesions and foam cells in these tissues. However, the administration of thyme extract attenuated HFD-caused alterations by decreasing blood lipids, elevating paraoxonase activity (+24.04%), and limiting the progression of atherosclerotic lesions.</p><p><strong>Conclusion: </strong>We conclude that the supplementation with the aqueous extract of T. atlanticus could potentially protect against hyperlipidemia and consequently, the development of atherosclerosis.</p>","PeriodicalId":93925,"journal":{"name":"Cardiovascular & hematological disorders drug targets","volume":" ","pages":"256-262"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<i>Thymus atlanticus</i> (Ball) Roussine Aqueous Extract Exerts Lipid-lowering and Anti-atherosclerotic Effects in Hyperlipidemic Guinea Pigs.\",\"authors\":\"Hamza Elbouny, Brahim Ouahzizi, Oussama Bekkouch, Amal Bennani, Souliman Amrani, Mhamed Ramchoun, Khalid Sellam, Chakib Alem\",\"doi\":\"10.2174/011871529X270863231123063744\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Thymus atlanticus (Ball) Roussine (T. atlanticus) is traditionally used in the Moroccan high Atlas Mountains to treat several disorders, including cardiovascular disease. 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引用次数: 0
摘要
背景:大西洋胸腺(球)Roussine (T. atlanticus)传统上在摩洛哥高阿特拉斯山脉用于治疗几种疾病,包括心血管疾病。本研究以慢性高脂血症豚鼠为实验对象,研究了传统的大西洋田鼠水提物的降脂和抗动脉粥样硬化活性。方法:饲喂含2%胆固醇和20%猪油的日粮12周。此外,百里香提取液每日给药400 mg/kg。实验结束时测定各组大鼠血脂水平和对氧磷酶芳酯酶活性,并进行主动脉组织学观察。结果:我们的研究结果显示,HFD组血脂显著升高,对氧磷酶芳酯酶活性显著降低(-40.06%)。此外,脂肪的消耗改变了主动脉的组织学,使内膜增厚,并在这些组织中形成动脉粥样硬化病变和泡沫细胞。然而,百里香提取物通过降低血脂、提高对氧磷酶活性(+24.04%)和限制动脉粥样硬化病变的进展,减轻了hfd引起的改变。结论:枸杞水提物具有一定的抗高脂血症和预防动脉粥样硬化的作用。
Thymus atlanticus (Ball) Roussine Aqueous Extract Exerts Lipid-lowering and Anti-atherosclerotic Effects in Hyperlipidemic Guinea Pigs.
Background: Thymus atlanticus (Ball) Roussine (T. atlanticus) is traditionally used in the Moroccan high Atlas Mountains to treat several disorders, including cardiovascular disease. In the present study, the lipid-lowering and anti-atherosclerotic activities of the traditionally used aqueous extract of T. atlanticus were evaluated on guinea pigs subjected to chronic hyperlipidemia.
Methods: Animals were given a diet containing 2% cholesterol and 20% lard for 12 weeks. Moreover, thyme extract was given daily at 400 mg/kg. At the end of the experiment, lipid levels and paraoxonase arylesterase activity were measured, and aorta histology was studied.
Results: Our findings revealed that there was an important elevation of blood lipids in the HFD group along with a significant decrease in paraoxonase arylesterase activity (-40.06%). Moreover, the consumption of fat altered the histology of aorta by thickening the intima media and forming atherosclerotic lesions and foam cells in these tissues. However, the administration of thyme extract attenuated HFD-caused alterations by decreasing blood lipids, elevating paraoxonase activity (+24.04%), and limiting the progression of atherosclerotic lesions.
Conclusion: We conclude that the supplementation with the aqueous extract of T. atlanticus could potentially protect against hyperlipidemia and consequently, the development of atherosclerosis.