心肌细胞周期的代谢控制。

Q2 Medicine

Methodist DeBakey cardiovascular journal Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI:10.14797/mdcvj.1309

Ivan Menendez-Montes, Daniel J Garry, Jianyi Jay Zhang, Hesham A Sadek

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引用次数: 0

摘要

目前治疗心力衰竭的目的是防止心肌损伤后发生的有害重塑，但目前没有治疗方法可以替代丢失的心肌细胞。目前正在研究的几种生物体能够通过现有心肌细胞的增殖来再生其心肌。在这篇综述中，我们总结了哺乳动物心脏的主要代谢途径，以及这些代谢途径如何通过遗传和药理学方法调节心肌细胞增殖和心脏再生。

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Metabolic Control of Cardiomyocyte Cell Cycle.

Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.

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来源期刊

Methodist DeBakey cardiovascular journal Medicine-Medicine (all)

CiteScore

2.30

自引率

0.00%

发文量