纯实体T1型肺癌侵袭性诊断与预测研究进展。

IF 5.1 4区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Precision Clinical Medicine Pub Date : 2023-08-17 eCollection Date: 2023-09-01 DOI:10.1093/pcmedi/pbad020
Junhao Mu, Jing Huang, Min Ao, Weiyi Li, Li Jiang, Li Yang
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引用次数: 0

摘要

越来越多的早期肺癌表现为恶性肺结节已被诊断,因为越来越多的采用低剂量螺旋计算机断层扫描。但最大尺寸≤3cm的纯实体T1肺癌虽然体积小,但并不总是处于早期。这种类型的癌症具有很强的侵袭性,与病理累及、转移、术后复发甚至死亡有关。但在临床上极易误诊或延误诊断,对人体健康构成严重威胁。据报道,T1期肺癌的淋巴结或胸外转移率>20%。因此,了解和识别纯实体T1型肺癌的侵袭性特征对预防、诊断和治疗策略至关重要,有利于改善预后。随着肺癌筛查的广泛开展,这些高侵袭性纯实体T1型肺癌将成为未来晚期肺癌的主要类型。然而,关于如何识别这些“早期”侵袭性肺癌的精准医学信息有限。本文综述了高侵袭性纯实体T1肺癌的临床特点、影像学、病理、基因改变、免疫微环境、多组学以及目前的诊断和预测技术,为临床医生提供早期识别和干预提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer.

A growing number of early-stage lung cancers presenting as malignant pulmonary nodules have been diagnosed because of the increased adoption of low-dose spiral computed tomography. But pure solid T1 lung cancer with ≤3 cm in the greatest dimension is not always at an early stage, despite its small size. This type of cancer can be highly aggressive and is associated with pathological involvement, metastasis, postoperative relapse, and even death. However, it is easily misdiagnosed or delay diagnosed in clinics and thus poses a serious threat to human health. The percentage of nodal or extrathoracic metastases has been reported to be >20% in T1 lung cancer. As such, understanding and identifying the aggressive characteristics of pure solid T1 lung cancer is crucial for prevention, diagnosis, and therapeutic strategies, and beneficial to improving the prognosis. With the widespread of lung cancer screening, these highly invasive pure solid T1 lung cancer will become the main advanced lung cancer in future. However, there is limited information regarding precision medicine on how to identify these "early-stage" aggressive lung cancers. To provide clinicians with new insights into early recognition and intervention of the highly invasive pure solid T1 lung cancer, this review summarizes its clinical characteristics, imaging, pathology, gene alterations, immune microenvironment, multi-omics, and current techniques for diagnosis and prediction.

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来源期刊
Precision Clinical Medicine
Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
10.80
自引率
0.00%
发文量
26
审稿时长
5 weeks
期刊介绍: Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.
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