含亚油酸的酰基葡萄糖神经酰胺、酰基神经酰胺与表皮通透性屏障形成相关的事件。

IF 2.8 4区医学 Q2 DERMATOLOGY

Skin Pharmacology and Physiology Pub Date : 2023-01-01 Epub Date: 2023-11-30 DOI:10.1159/000535049

Philip W Wertz

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引用次数: 0

摘要

背景:活表皮中含亚油酸酰基葡萄糖神经酰胺(GLC-CER[EOx]，其中x =鞘磷脂(S)、二氢鞘磷脂(dS)、植鞘磷脂(P)或6-羟基鞘磷脂(H))是角质层(SC)和角化脂质包膜(CLE)中含亚油酸酰基神经酰胺(CER[EOx])的前体，两者对于皮肤的屏障功能都是必不可少的。总结:CLE的形成和包膜成熟发生在整个SC中。表皮的缺氧条件和乳酸的厌氧糖酵解对SC屏障的形成很重要。关键信息:CLE形成横跨角质层。它是由含亚油酸的酰基葡萄糖神经酰胺形成的，需要脂氧合酶的作用，但导致乳酸生成的厌氧条件和缺氧诱导因子对于适当的屏障形成是必不可少的。关于CLE和表皮渗透性屏障的形成，提出了许多悬而未决的问题。

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Linoleate-Containing Acylglucosylceramide, Acylceramide, and Events Associated with Formation of the Epidermal Permeability Barrier.

Background: Linoleate-containing acylglucosylceramide (GLC-CER[EOx], where x = sphingosine [S], dihydrosphingosine [dS], phytosphingosine (P), or 6-hydroxysphingosine [H]) in the viable epidermis serve as the precursors to the linoleate-containing acylceramides (CER[EOx]) in the stratum corneum (SC) and the corneocyte lipid envelope (CLE), both of which are essential for the barrier function of the skin.

Summary: CLE formation and envelope maturation take place across the SC. Hypoxic conditions in the epidermis and anaerobic glycolysis with the production of lactic acid are important in proper SC barrier formation.

Key message: CLE formation takes place across the SC. Its formation from linoleate-containing GLC-CER[EOx] requires lipoxygenase action, but anaerobic conditions leading to lactate production and hypoxia-inducible factors are essential for proper barrier formation. A number of unanswered questions are raised regarding formation of the CLE and the epidermal permeability barrier.

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来源期刊

Skin Pharmacology and Physiology 医学-皮肤病学

CiteScore

5.20

自引率

7.40%

发文量

审稿时长

>12 weeks

期刊介绍： In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.