地中海贫血患者脑血管疾病的改良磁共振成像负担及相关危险因素

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY

Neurologist Pub Date : 2024-03-01 DOI:10.1097/NRL.0000000000000541

Xiuying Liu, Kunling Yang, Lanfeng Sun, Qi Huang, Lianqing Long, Sijie Ou, Xing Wei, Yuan Wu

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引用次数: 0

摘要

目的:探讨地中海贫血患者小脑血管病(CSVD)的磁共振成像(MRI)负担及相关危险因素。方法:回顾性分析地中海贫血患者的临床资料和MRI，并选择性别、年龄相匹配的非地中海贫血对照。CSVD的改良MRI负担包括近期皮质下小梗死，推定血管源性白质高，推定血管源性腔隙，血管周围间隙(PVS)和脑萎缩。结果:本研究包括地中海贫血和对照组各110例患者。两组患者在性别、年龄、常见脑血管疾病危险因素等方面无显著差异。地中海贫血患者红细胞计数较高，血红蛋白含量较低。地中海贫血组的PVS和改良MRI负担评分高于对照组。随着年龄的增长，地中海贫血患者有更严重的心血管疾病负担。结论:与非地中海贫血患者相比，地中海贫血患者CSVD的改良MRI负担更重，尤其是PVS，年龄是CSVD改变的重要危险因素。

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Modified Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease and Related Risk Factors in Patients With Thalassemia.

Objective: This study aimed to explore the burden of magnetic resonance imaging (MRI) of cerebral small vessel disease (CSVD) in patients with thalassemia and related risk factors.

Methods: The clinical data and MRI of patients with thalassemia were retrospectively analyzed, and non-thalassemia controls with matched sex and age were selected. The modified MRI burden of CSVD included recent small subcortical infarct, presumed vasogenic white matter hyperintensity, presumed vasogenic lacunae, perivascular space (PVS), and brain atrophy.

Results: This study included 110 patients in each of the thalassemia and control groups. There was no significant difference in sex, age, and common cerebrovascular disease risk factors between the 2 groups. The patients with thalassemia had a higher red blood cell count and lower content of hemoglobin. The PVS and modified MRI burden scores in the thalassemia group were higher than in the control group. With the increase in age, patients with thalassemia have a more severe CSVD burden.

Conclusion: Patients with thalassemia have a heavier modified MRI burden of CSVD than non-thalassemia patients, particularly PVS, and aging is an important risk factor for CSVD changes.

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来源期刊

Neurologist 医学-临床神经学

CiteScore

1.90

自引率

0.00%

发文量

151

审稿时长

2 months

期刊介绍： The Neurologist publishes articles on topics of current interest to physicians treating patients with neurological diseases. The core of the journal is review articles focusing on clinically relevant issues. The journal also publishes case reports or case series which review the literature and put observations in perspective, as well as letters to the editor. Special features include the popular "10 Most Commonly Asked Questions" and the "Patient and Family Fact Sheet," a handy tear-out page that can be copied to hand out to patients and their caregivers.