基于间充质干细胞/基质细胞治疗酒精相关性肝病和非酒精性脂肪肝的最新进展

IF 5.4 2区 医学 Q1 CELL & TISSUE ENGINEERING
Foteini Korkida, Alexandra Stamatopoulou, Maria G Roubelakis
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引用次数: 0

摘要

酒精相关性肝病(ALD)和非酒精性脂肪性肝病(NAFLD)代表了包括许多不同阶段的病理状况,可能导致肝硬化的最后阶段。迄今为止,肝移植是唯一成功的治疗方法,伴有供体器官短缺和需要终身免疫抑制治疗的局限性。最近,以间充质干细胞/基质细胞(MSCs)为基础的细胞疗法被提出用于ALD和NAFLD。MSC治疗应用提供肝保护,调节炎症过程和血管生成,特别是在ALD和NAFLD临床前疾病模型中。最近的研究表明,基于肝特异性msc的治疗可以通过恢复肝功能和减少炎症和纤维化而使肝脏疾病受益。与实体器官移植类似,间充质干细胞方法的局限性包括供体的可获得性因大量细胞和细胞被困入肺而加剧。在此,基于最近的进展,我们讨论了MSCs作为ALD和NAFLD的治疗方法的使用,并为建立一个潜在的临床应用框架提供了可用的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Advances in Mesenchymal Stem/Stromal Cell-Based Therapy for Alcohol-Associated Liver Disease and Non-alcoholic Fatty Liver Disease.

Alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) represent pathological conditions that include many distinct stages, potentially leading to the final stage of cirrhotic liver. To date, liver transplantation is the sole successful treatment with concomitant limitations related to donor organ shortage and the need of life-long immunosuppressive therapy. Recently, cell-based therapies for ALD and NAFLD have been proposed with mesenchymal stem/stromal cells (MSCs) as promising effectors. MSC therapeutic applications offer hepatoprotection, regulation of the inflammatory process and angiogenesis particularly in ALD and NAFLD pre-clinical disease models. Recent studies suggested that hepatospecific MSC-based therapies could benefit liver diseases by restoring liver function and decreasing inflammation and fibrosis. Similarly to solid-organ transplantation, limitations in MSC approaches include donor availability exacerbated by high number of cells and cell trapping into lungs. Herein, based on recent advances, we discuss the use of MSCs as a therapeutic approach for ALD and NAFLD and we provide the available information for the establishment of a framework toward a potential clinical application.

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来源期刊
Stem Cells Translational Medicine
Stem Cells Translational Medicine CELL & TISSUE ENGINEERING-
CiteScore
12.90
自引率
3.30%
发文量
140
审稿时长
6-12 weeks
期刊介绍: STEM CELLS Translational Medicine is a monthly, peer-reviewed, largely online, open access journal. STEM CELLS Translational Medicine works to advance the utilization of cells for clinical therapy. By bridging stem cell molecular and biological research and helping speed translations of emerging lab discoveries into clinical trials, STEM CELLS Translational Medicine will help move applications of these critical investigations closer to accepted best patient practices and ultimately improve outcomes. The journal encourages original research articles and concise reviews describing laboratory investigations of stem cells, including their characterization and manipulation, and the translation of their clinical aspects of from the bench to patient care. STEM CELLS Translational Medicine covers all aspects of translational cell studies, including bench research, first-in-human case studies, and relevant clinical trials.
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