干粉吸入器:概述

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM
Anthony J Hickey
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引用次数: 0

摘要

干粉吸入器产品在治疗和预防哮喘以及最近的慢性阻塞性肺病方面发挥了重要作用。支持这些产品的配方开发的考虑因素涵盖了一系列独特的学科,包括分析和物理化学,气溶胶物理,设备技术,工艺工程和工业设计。在过去的半个世纪里,人们花费了巨大的研究努力来了解这种复杂的剂型。考虑开发干粉吸入器产品的指导原则包括疾病治疗的要求,采用某些技术方法的优点和局限性,以及方便患者使用的理想功能,这些都体现在目标产品简介中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dry Powder Inhalers: An Overview.

Dry powder inhaler products have played an important role in the treatment and prevention of asthma and more recently chronic obstructive pulmonary disease. The considerations that go into formulation development to support these products cover a unique range of disciplines including analytical and physical chemistry, aerosol physics, device technology, process engineering and industrial design. An enormous research effort has been expended in the last half century to provide understanding of this complex dosage form. The guiding principles in considering the development of dry powder inhaler products encompass requirements for disease therapy, advantages and limitations of adopting certain technological approaches, and desirable features to facilitate patient use, which are all embodied in the target product profile.

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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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