与去神经支配诱导的骨骼肌萎缩相关的可溶性因子。

IF 1.9 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Marianny Portal Rodríguez, Claudio Cabello-Verrugio
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引用次数: 0

摘要

骨骼肌组织具有保护人体的关键机械支撑功能。此外,其功能还受到结构蛋白和调节蛋白的平衡合成和降解过程的强烈影响。蛋白质合成的抑制和/或分解代谢的激活通常决定了一种称为肌肉萎缩的病理状态或状况,肌肉质量的减少导致部分或全部功能丧失。已经确定,许多病理生理条件可导致肌肉量减少。骨骼肌神经支配通过神经肌肉连接与肌肉进行稳定和功能性的神经相互作用,对维持正常的肌肉结构和功能至关重要。运动神经支配的丧失导致骨骼肌纤维快速变性,伴有萎缩相关信号的激活和随后的肌节分解,改变正常的肌肉功能。在去神经支配后,炎症阶段的特征是决定肌肉萎缩的促炎细胞因子的表达增加。在这篇综述中,我们强调了一些可溶性因子在去神经支配肌萎缩发展中的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Soluble Factors Associated with Denervation-induced Skeletal Muscle Atrophy.

Skeletal muscle tissue has the critical function of mechanical support protecting the body. In addition, its functions are strongly influenced by the balanced synthesis and degradation processes of structural and regulatory proteins. The inhibition of protein synthesis and/or the activation of catabolism generally determines a pathological state or condition called muscle atrophy, a reduction in muscle mass that results in partial or total loss of function. It has been established that many pathophysiological conditions can cause a decrease in muscle mass. Skeletal muscle innervation involves stable and functional neural interactions with muscles via neuromuscular junctions and is essential for maintaining normal muscle structure and function. Loss of motor innervation induces rapid skeletal muscle fiber degeneration with activation of atrophy-related signaling and subsequent disassembly of sarcomeres, altering normal muscle function. After denervation, an inflammation stage is characterized by the increased expression of pro-inflammatory cytokines that determine muscle atrophy. In this review, we highlighted the impact of some soluble factors on the development of muscle atrophy by denervation.

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来源期刊
Current protein & peptide science
Current protein & peptide science 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.
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