RsaM:一个独特的优势调节AHL群体感应细菌。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Vittorio Venturi, Mihael Špacapan, Nemanja Ristović, Cristina Bez
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引用次数: 0

摘要

群体感应(Quorum sensing, QS)是一种由LuxI/LuxR蛋白家族对调控基因表达的机制,其产生并响应n -酰基高丝氨酸内酯(N-acyl homoserine lactone, AHL)扩散信号分子。QS通常被认为是通过对ahl浓度的感知/响应而产生的细胞密度反应,ahl主要是由细菌细胞不断产生的。然而,luxI/R系统在对外界刺激的反应中进行超调节,许多调节因子与控制细菌的QS有关,尽管目前尚不清楚这些调节因子和提示因子如何促进QS反应。一种被称为RsaM的调节因子,据报道在一些蛋白质细菌物种中对AHL QS的控制有严格的作用。rsam很小,长度在140-170 aa之间,存在于几个属中,主要存在于伯克霍尔德氏菌和不动杆菌中。编码RsaM的基因总是被定位为一个独立的转录单元,位于QS luxI和/或luxR位点附近。RsaM最引人注目的方面之一是它的独特性;它不属于任何已知的细菌调节家族,它具有独特而新颖的折叠,不表现出与核酸或ahl的结合亲和力。RsaM在细菌中作为一种独特的调节剂脱颖而出,因为它可能具有重要的生态作用,同时也揭示了细菌基因调控的一种新方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RsaM: a unique dominant regulator of AHL quorum sensing in bacteria.

Quorum sensing (QS) in proteobacteria is a mechanism to control gene expression orchestrated by the LuxI/LuxR protein family pair, which produces and responds to N-acyl homoserine lactone (AHL) diffusible signal molecules. QS is often regarded as a cell density response via the sensing of/response to the concentrations of AHLs, which are constantly basally produced by bacterial cells. The luxI/R systems, however, undergo supra-regulation in response to external stimuli and many regulators have been implicated in controlling QS in bacteria, although it remains unclear how most of these regulators and cues contribute to the QS response. One regulator, called RsaM, has been reported in a few proteobacterial species to have a stringent role in the control of AHL QS. RsaMs are small, in the range of 140-170 aa long, and are found in several genera, principally in Burkholderia and Acinetobacter. The gene encoding RsaM is always located as an independent transcriptional unit, situated adjacent to QS luxI and/or luxR loci. One of the most remarkable aspects of RsaM is its uniqueness; it does not fall into any of the known bacterial regulatory families and it possesses a distinct and novel fold that does not exhibit binding affinity for nucleic acids or AHLs. RsaM stands out as a distinctive regulator in bacteria, as it is likely to have an important ecological role, as well as unravelling a novel way of gene regulation in bacteria.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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