视网膜血管对缺氧反应的改变:一项高海拔探险研究。

IF 1.6 4区 医学 Q4 BIOPHYSICS
High altitude medicine & biology Pub Date : 2024-03-01 Epub Date: 2023-11-23 DOI:10.1089/ham.2023.0084
Jessica Westwood, India Mayhook-Walker, Ciaran Simpkins, Andrew Darby-Smith, Dan Morris, Eduardo Normando
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引用次数: 0

摘要

韦斯特伍德、杰西卡、英迪亚·梅胡克-沃克、西阿兰·辛普金斯、安德鲁·达比-史密斯、丹·莫里斯和爱德华多·诺曼多。视网膜血管对缺氧反应的改变:一项高海拔探险研究。中国生物医学工程学报(英文版),2023。背景:视网膜血管弯曲和扩张的增加是对缺氧的生理反应。这可能导致高原视网膜病变(HAR),但发病率报告变化很大,我们对病因机制的理解仍然不完整。这项研究定量评估了4,167米探险期间视网膜血管的变化。方法:10名健康参与者登上摩洛哥的Toubkal山。眼底图像在出发前,在整个考察期间每天拍摄,并在返回后1个月拍摄。除了血管密度和HAR特征外,还评估了4条血管的直径和弯曲度。结果:高海拔暴露日,多只血管弯曲度和内径均显著增加(p≤0.05)。海拔高度与探险第2、3、6天的颞上视网膜动脉直径有较强的相关性(r分别为0.7707、0.7951、0.7401;p结论:在这个队列中观察到生理性而非病理性的变化,这使我们深入了解整个探险过程中脑血管系统的状态。这些结果可能归因于相对较低的海拔暴露,保守的上升剖面和队列的人口统计。未来的研究必须包括每天在高海拔地区的视网膜图像,并采取措施减少环境干扰。本研究适用于高原旅游者、糖尿病视网膜病变或视网膜静脉闭塞患者、危重患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retinal Vascular Changes in Response to Hypoxia: A High-Altitude Expedition Study.

Westwood, Jessica, India Mayhook-Walker, Ciaran Simpkins, Andrew Darby-Smith, Dan Morris, and Eduardo Normando. Retinal vascular changes in response to hypoxia: a high-altitude expedition study. High Alt Med Biol. 25:49-59, 2024. Background: Increased tortuosity and engorgement of retinal vasculature are recognized physiological responses to hypoxia. This can lead to high-altitude retinopathy (HAR), but incidence reports are highly variable, and our understanding of the etiological mechanisms remains incomplete. This study quantitatively evaluated retinal vascular changes during an expedition to 4,167 m. Methods: Ten healthy participants summited Mount Toubkal, Morocco. Fundus images were taken predeparture, daily throughout the expedition, and 1 month postreturn. Diameter and tortuosity of four vessels were assessed, in addition to vessel density and features of HAR. Results: Significant (p ≤ 0.05) increases in tortuosity and diameter were observed in several vessels on high-altitude exposure days. There was a strong correlation between altitude and supratemporal retinal artery diameter on days 2, 3, and 6 of the expedition (r = 0.7707, 0.7951, 0.7401, respectively; p < 0.05). There was a significant increase in median vessel density from 6.7% at baseline to 10.0% on summit day. Notably there were no incidences of HAR. Conclusion: Physiological but not pathological changes were seen in this cohort, which gives insight into the state of the cerebral vasculature throughout this expedition. These results are likely attributable to relatively low altitude exposure, a conservative ascent profile, and the cohort's demographic. Future study must include daily retinal images at higher altitudes and take steps to mitigate environmental confounders. This study is relevant to altitude tourists, patients with diabetic retinopathy or retinal vein occlusion, and critically ill patients.

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来源期刊
High altitude medicine & biology
High altitude medicine & biology 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.80
自引率
9.50%
发文量
44
审稿时长
>12 weeks
期刊介绍: High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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