儿科医院外科病房SARS-CoV-2抗体血清阳性率:中低收入国家视角

IF 1.8 4区 医学 Q2 PEDIATRICS
Murad Habib, Noshela Javed, Sadia Asmat Burki, Mansoor Ahmed, Muhammad Amjad Chaudhary
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引用次数: 0

摘要

背景:我们研究的目的是测量和了解巴基斯坦儿科医院外科病房患者的抗sars - cov -2抗体的血清阳性情况。方法:一项前瞻性队列研究于2021年1月1日至2021年6月1日在巴基斯坦一家三级儿科医院外科病房进行,纳入的新生儿和1天至13岁的儿童。来自三个不同儿科阶层的所有患者[新生儿(1岁)]均被纳入研究。结果:600例患者入组,426例患者纳入研究。426例患者中,男性234例(54.9%),女性192例(45.1%)。总体而言,只有118例(27.7%)患者出现症状。其余308例(72.3%)无症状,其中发热28例(9.1%),咳嗽28例(9.1%),身体疼痛38例(12.33%),呕吐/腹泻292例(94.8%),嗅觉和味觉丧失28例(9.1%)。结果血清阳性的占27.7% (n = 118),抗体滴度阴性的占72.3% (n = 308)。结论:我们儿科外科病房的儿童SARS-CoV-2负担为27.7%,远高于文献报道的儿科医院或儿科外科病房儿童的6.8%。与COVID-19大流行早期的报告相反,本研究确定儿童承受着COVID-19感染的沉重负担。因此,儿童在SARS-CoV-2大流行中显得非常重要,因为他们是病毒的避难所,需要做进一步的研究,以确定他们是否在无声地传播疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seroprevalence of SARS-CoV-2 antibodies in pediatric hospital surgical unit: a lower-middle-income country perspective.

Background: The objective of our study was to measure and give insight into the seropositivity of anti-SARS-CoV-2 antibodies in the patients in our pediatric hospital surgical unit in Pakistan.

Methods: A prospective cohort study was conducted at a tertiary care pediatric hospital surgical unit in Pakistan between 1 January 2021 and 1 June 2021 on the enrolled neonates and children aged 1 day to 13 years. All patients from three different pediatric strata [neonates (<1 month), infants (1 to 12 months) and children (>1 year)] were enrolled in the study.

Results: Six-hundred patients were enrolled, and 426 patients were included in the study. Among 426 patients, 234 (54.9%) were male, and 192 (45.1%) were female. Overall only 118 (27.7%) patients developed symptoms. The other 308 (72.3%) were asymptomatic of which 28 (9.1%) had fever, 28 (9.1%) had cough, 38 (12.33%) had body aches, 292 (94.8%) had vomiting/diarrhea, and only 28 (9.1%) developed loss of smell and taste. Our results showed seropositivity of 27.7% (n = 118), while 72.3% (n = 308) had negative antibody titers.

Conclusion: A much higher pediatric SARS-CoV-2 burden of 27.7% was found in our pediatric surgical unit than has previously been reported in the literature of 6.8% for children in pediatric hospitals or pediatric surgical units. Contrary to reporting early in the COVID-19 pandemic, this study determined that children experience a significant burden of COVID-19 infection. Thus, children appear very important in SARS-CoV-2 pandemic, from harboring the virus and further studies need to be done to find if they are transmitting the disease silently.

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来源期刊
Journal of Tropical Pediatrics
Journal of Tropical Pediatrics 医学-热带医学
CiteScore
4.00
自引率
0.00%
发文量
97
审稿时长
6-12 weeks
期刊介绍: The Journal of Tropical Pediatrics provides a link between theory and practice in the field. Papers report key results of clinical and community research, and considerations of programme development. More general descriptive pieces are included when they have application to work preceeding elsewhere. The journal also presents review articles, book reviews and, occasionally, short monographs and selections of important papers delivered at relevant conferences.
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