祖父母暴露对孙辈心理健康的多代影响的范围综述。

IF 7.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Current Environmental Health Reports Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI:10.1007/s40572-023-00413-8
Jingyuan Xiao, Anushka Jain, Giselle Bellia, Kate Nyhan, Zeyan Liew
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引用次数: 0

摘要

综述目的:祖父母暴露对孙辈心理健康和神经发育的多代影响正受到研究的关注。我们进行了一项范围综述,以总结当前的流行病学研究,这些研究调查了影响祖父母怀孕及其孙辈心理健康结果的妊娠相关因素和环境因素。我们还确定了影响这些多代健康研究的方法学挑战,并讨论了未来研究的机会。最新发现:我们使用PubMed和Embase进行了文献检索,纳入了18篇文章。调查最多的祖父母怀孕相关因素是祖父母怀孕年龄(N = 6),怀孕期间吸烟(N = 4)和药物摄入(N = 3)。最常检查的孙子结果是自闭症谱系障碍(N = 6)和注意缺陷/多动障碍(N = 4)。在这些研究中,祖父母吸烟和使用己烯雌酚更一致地报道与神经发育障碍有关。而对祖父母年龄的研究结果在母系和父系之间有所不同。祖母体重、不良分娩结果以及其他生理和社会环境压力因素的时空标志需要进一步研究。目前的文献表明,精神和神经发育障碍可能是祖父母辈在怀孕期间不良暴露的结果。为了推进这一领域,我们建议开展多代研究,前瞻性地收集至少三代人的数据,将空间、环境和生物标记纳入暴露评估,扩大评估的结果表型,并建立一个因果分析框架,包括针对多代研究的中介分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A scoping review of multigenerational impacts of grandparental exposures on mental health in grandchildren.

Purpose of review: The multigenerational effects of grandparental exposures on their grandchildren's mental health and neurodevelopment are gaining research attention. We conducted a scoping review to summarize the current epidemiological studies investigating pregnancy-related and environmental factors that affected grandparental pregnancies and mental health outcomes in their grandchildren. We also identified methodological challenges that affect these multigenerational health studies and discuss opportunities for future research.

Recent findings: We performed a literature search using PubMed and Embase and included 18 articles for this review. The most investigated grandparental pregnancy-related factors were the grandparental age of pregnancy (N = 6), smoking during pregnancy (N = 4), and medication intake (N = 3). The most frequently examined grandchild outcomes were autism spectrum disorder (N = 6) and attention-deficit/hyperactivity disorder (N = 4). Among these studies, grandparental smoking and the use of diethylstilbestrol were more consistently reported to be associated with neurodevelopmental disorders, while the findings for grandparental age vary across the maternal or paternal line. Grandmaternal weight, adverse delivery outcomes, and other spatial-temporal markers of physical and social environmental stressors require further scrutiny. The current body of literature has suggested that mental and neurodevelopmental disorders may be outcomes of unfavorable exposures originating from the grandparental generation during their pregnancies. To advance the field, we recommend research efforts into setting up multigenerational studies with prospectively collected data that span through at least three generations, incorporating spatial, environmental, and biological markers for exposure assessment, expanding the outcome phenotypes evaluated, and developing a causal analytical framework including mediation analyses specific for multigenerational research.

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来源期刊
CiteScore
13.60
自引率
1.30%
发文量
47
期刊介绍: Current Environmental Health Reports provides up-to-date expert reviews in environmental health. The goal is to evaluate and synthesize original research in all disciplines relevant for environmental health sciences, including basic research, clinical research, epidemiology, and environmental policy.
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