巨噬细胞膜和脂质介质在心血管疾病中与清道夫受体的相互作用。

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sangeetha Ravi , Livya Catherene Martin , Mahalakshmi Krishnan , Manikandan Kumaresan , Beulaja Manikandan , Manikandan Ramar
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引用次数: 0

摘要

以动脉粥样硬化为主要潜在原因的心血管疾病的发生和发展发生在血管系统,特别是动脉壁内的慢性炎症持续期间。这种长期的不适应炎症是由巨噬细胞驱动的,其关键介质通常归因于脂质代谢的差异。巨噬细胞是先天免疫的原代细胞,具有扩张性膜结构域,通过其信号系统参与免疫应答。在动脉粥样硬化过程中,膜结构域和受体控制着巨噬细胞的各种活性组织。它们的清道夫/内吞受体调节细胞内和细胞外货物的运输。对脂质代谢的相应影响是通过它们与清净膜受体的动态相互作用以及它们的综合机制(如胞饮作用、吞噬作用、胆固醇输出/输入等)介导的。这种相互作用不仅导致巨噬细胞的功能分化,而且改变了巨噬细胞的结构构型。在这里,我们回顾了巨噬细胞膜生物力学及其清道夫受体家族与动脉粥样硬化过程中脂质代谢产物的关系。此外,还详细介绍了巨噬细胞的膜结构和参与内吞与脂质代谢的信号通路。本文建立了对清道夫受体作为心血管疾病预防和治疗的潜在靶点的未来见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Interactions between macrophage membrane and lipid mediators during cardiovascular diseases with the implications of scavenger receptors

Interactions between macrophage membrane and lipid mediators during cardiovascular diseases with the implications of scavenger receptors

The onset and progression of cardiovascular diseases with the major underlying cause being atherosclerosis, occur during chronic inflammatory persistence in the vascular system, especially within the arterial wall. Such prolonged maladaptive inflammation is driven by macrophages and their key mediators are generally attributed to a disparity in lipid metabolism. Macrophages are the primary cells of innate immunity, endowed with expansive membrane domains involved in immune responses with their signalling systems. During atherosclerosis, the membrane domains and receptors control various active organisations of macrophages. Their scavenger/endocytic receptors regulate the trafficking of intracellular and extracellular cargo. Corresponding influence on lipid metabolism is mediated by their dynamic interaction with scavenger membrane receptors and their integrated mechanisms such as pinocytosis, phagocytosis, cholesterol export/import, etc. This interaction not only results in the functional differentiation of macrophages but also modifies their structural configurations. Here, we reviewed the association of macrophage membrane biomechanics and their scavenger receptor families with lipid metabolites during the event of atherogenesis. In addition, the membrane structure of macrophages and the signalling pathways involved in endocytosis integrated with lipid metabolism are detailed. This article establishes future insights into the scavenger receptors as potential targets for cardiovascular disease prevention and treatment.

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来源期刊
Chemistry and Physics of Lipids
Chemistry and Physics of Lipids 生物-生化与分子生物学
CiteScore
7.60
自引率
2.90%
发文量
50
审稿时长
40 days
期刊介绍: Chemistry and Physics of Lipids publishes research papers and review articles on chemical and physical aspects of lipids with primary emphasis on the relationship of these properties to biological functions and to biomedical applications. Accordingly, the journal covers: advances in synthetic and analytical lipid methodology; mass-spectrometry of lipids; chemical and physical characterisation of isolated structures; thermodynamics, phase behaviour, topology and dynamics of lipid assemblies; physicochemical studies into lipid-lipid and lipid-protein interactions in lipoproteins and in natural and model membranes; movement of lipids within, across and between membranes; intracellular lipid transfer; structure-function relationships and the nature of lipid-derived second messengers; chemical, physical and functional alterations of lipids induced by free radicals; enzymatic and non-enzymatic mechanisms of lipid peroxidation in cells, tissues, biofluids; oxidative lipidomics; and the role of lipids in the regulation of membrane-dependent biological processes.
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