toll样受体4 (TLR4):免疫与衰老的新认识。

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Hyo-Jin Kim, Hyemin Kim, Jeong-Hyung Lee, Cheol Hwangbo
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引用次数: 0

摘要

TLR4是一种跨膜受体,在先天免疫应答中起核心作用。TLR4不仅与细胞膜表面的外源性配体结合,还与细胞内配体相互作用,启动复杂的细胞内信号级联反应。TLR4通过接头蛋白MyD88激活转录因子NF-κB和AP-1,从而促进促炎细胞因子的上调。另一种与TLR4连接的适配器蛋白,称为TRIF,自主传播信号通路,导致干扰素表达增加。近年来,TLR4作为调控衰老相关疾病症状的一个重要因素引起了人们的关注。TLR4引发的持续炎症反应有助于这些疾病的发生和恶化。此外,TLR4表达水平的改变在改变年龄相关疾病的表现中起着关键作用。在这篇综述中,我们旨在巩固TLR4对细胞衰老和衰老相关疾病的影响,强调TLR4作为一种超越免疫反应的新型治疗靶点的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toll-like receptor 4 (TLR4): new insight immune and aging.

TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane's surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades. Through MyD88, an adaptor protein, TLR4 activates transcription factors NF-κB and AP-1, thereby facilitating the upregulation of pro-inflammatory cytokines. Another adapter protein linked to TLR4, known as TRIF, autonomously propagates signaling pathways, resulting in heightened interferon expression. Recently, TLR4 has garnered attention as a significant factor in the regulation of symptoms in aging-related disorders. The persistent inflammatory response triggered by TLR4 contributes to the onset and exacerbation of these disorders. In addition, alterations in TLR4 expression levels play a pivotal role in modifying the manifestations of age-related diseases. In this review, we aim to consolidate the impact of TLR4 on cellular senescence and aging-related ailments, highlighting the potential of TLR4 as a novel therapeutic target that extends beyond immune responses.

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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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