猪小儿急性呼吸窘迫综合征模型的间接心输出量评估。

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2023-11-23 DOI:10.1016/j.resp.2023.104199

Lorenzo A. Miller , Rudolf K. Braun , Regina J. Golding , Michael Lasarev , Allison C. Rodgers , Sarah El-Meanawy , Timothy A. Hacker , Marlowe W. Eldridge , Awni M. Al-Subu

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引用次数: 0

摘要

目的:探讨猪小儿急性呼吸窘迫综合征(ARDS)模型的二氧化碳消除量(V / CO2)和潮末二氧化碳(PETCO2)与心输出量(CO)的相关性。方法:采用油酸输注方法，对26头全麻机械通气仔猪在诱导ARDS前后的呼吸和血流动力学指标进行测定。结果:ARDS诱导前，平均(SD) CO、V (CO2)、PETCO2和死空潮容比(Vd/Vt)分别为4.16 (1.10)L/min、103.69 (18.06)ml/min、40.72 (3.88)mmHg和0.25(0.09)。平均CO、V³CO2和PETCO2的偏相关系数分别为0.44(95%可信区间0.18 ~ 0.69)和0.50(95%可信区间0.18 ~ 0.74)。ARDS诱导后，平均CO、V / CO2、PETCO2、Vd/Vt分别为3.33 (0.97)L/min、113.71 (22.97)ml/min、50.17 (9.73)mmHg、0.40(0.08)。CO与V ~ CO2的偏相关为0.01 (-0.31 ~ 0.37)，CO与PETCO2的偏相关为0.35(-0.002 ~ 0.65)。结论:ARDS可能限制容积容积造影监测CO的应用。

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Indirect cardiac output assessment in a swine pediatric acute respiratory distress syndrome model

Purpose

To investigate the correlation between volume of carbon dioxide elimination (V̇CO₂) and end-tidal carbon dioxide (PETCO₂) with cardiac output (CO) in a swine pediatric acute respiratory distress syndrome (ARDS) model.

Methods

Respiratory and hemodynamic variables were collected from twenty-six mechanically ventilated juvenile pigs under general anesthesia before and after inducing ARDS, using oleic acid infusion.

Results

Prior to ARDS induction, mean (SD) CO, V̇CO₂, PETCO₂, and dead space to tidal volume ratio (V_d/V_t) were 4.16 (1.10) L/min, 103.69 (18.06) ml/min, 40.72 (3.88) mmHg and 0.25 (0.09) respectively. Partial correlation coefficients between average CO, V̇CO₂, and PETCO₂ were 0.44 (95% confidence interval: 0.18–0.69) and 0.50 (0.18–0.74), respectively. After ARDS induction, mean CO, V̇CO₂, PETCO₂, and V_d/V_t were 3.33 (0.97) L/min, 113.71 (22.97) ml/min, 50.17 (9.73) mmHg and 0.40 (0.08). Partial correlations between CO and V̇CO₂ was 0.01 (−0.31 to 0.37) and between CO and PETCO₂ was 0.35 (−0.002 to 0.65).

Conclusion

ARDS may limit the utility of volumetric capnography to monitor CO.

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.