Lorenzo A. Miller , Rudolf K. Braun , Regina J. Golding , Michael Lasarev , Allison C. Rodgers , Sarah El-Meanawy , Timothy A. Hacker , Marlowe W. Eldridge , Awni M. Al-Subu
{"title":"猪小儿急性呼吸窘迫综合征模型的间接心输出量评估。","authors":"Lorenzo A. Miller , Rudolf K. Braun , Regina J. Golding , Michael Lasarev , Allison C. Rodgers , Sarah El-Meanawy , Timothy A. Hacker , Marlowe W. Eldridge , Awni M. Al-Subu","doi":"10.1016/j.resp.2023.104199","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the correlation between volume of carbon dioxide elimination (V̇CO<sub>2</sub>) and end-tidal carbon dioxide (PETCO<sub>2</sub><span><span>) with cardiac output (CO) in a swine pediatric </span>acute respiratory distress syndrome </span><strong>(</strong>ARDS) model.</p></div><div><h3>Methods</h3><p><span><span>Respiratory and hemodynamic variables were collected from twenty-six mechanically ventilated juvenile pigs under </span>general anesthesia before and after inducing ARDS, using </span>oleic acid infusion.</p></div><div><h3>Results</h3><p>Prior to ARDS induction, mean (SD) CO, V̇CO<sub>2</sub>, PETCO<sub>2</sub><span>, and dead space to tidal volume ratio (V</span><sub>d</sub>/V<sub>t</sub>) were 4.16 (1.10) L/min, 103.69 (18.06) ml/min, 40.72 (3.88) mmHg and 0.25 (0.09) respectively. Partial correlation coefficients between average CO, V̇CO<sub>2</sub>, and PETCO<sub>2</sub> were 0.44 (95% confidence interval: 0.18–0.69) and 0.50 (0.18–0.74), respectively. After ARDS induction, mean CO, V̇CO<sub>2</sub>, PETCO<sub>2</sub>, and V<sub>d</sub>/V<sub>t</sub> were 3.33 (0.97) L/min, 113.71 (22.97) ml/min, 50.17 (9.73) mmHg and 0.40 (0.08). Partial correlations between CO and V̇CO<sub>2</sub> was 0.01 (−0.31 to 0.37) and between CO and PETCO<sub>2</sub> was 0.35 (−0.002 to 0.65).</p></div><div><h3>Conclusion</h3><p>ARDS may limit the utility of volumetric capnography to monitor CO.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Indirect cardiac output assessment in a swine pediatric acute respiratory distress syndrome model\",\"authors\":\"Lorenzo A. Miller , Rudolf K. Braun , Regina J. Golding , Michael Lasarev , Allison C. Rodgers , Sarah El-Meanawy , Timothy A. Hacker , Marlowe W. Eldridge , Awni M. Al-Subu\",\"doi\":\"10.1016/j.resp.2023.104199\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>To investigate the correlation between volume of carbon dioxide elimination (V̇CO<sub>2</sub>) and end-tidal carbon dioxide (PETCO<sub>2</sub><span><span>) with cardiac output (CO) in a swine pediatric </span>acute respiratory distress syndrome </span><strong>(</strong>ARDS) model.</p></div><div><h3>Methods</h3><p><span><span>Respiratory and hemodynamic variables were collected from twenty-six mechanically ventilated juvenile pigs under </span>general anesthesia before and after inducing ARDS, using </span>oleic acid infusion.</p></div><div><h3>Results</h3><p>Prior to ARDS induction, mean (SD) CO, V̇CO<sub>2</sub>, PETCO<sub>2</sub><span>, and dead space to tidal volume ratio (V</span><sub>d</sub>/V<sub>t</sub>) were 4.16 (1.10) L/min, 103.69 (18.06) ml/min, 40.72 (3.88) mmHg and 0.25 (0.09) respectively. Partial correlation coefficients between average CO, V̇CO<sub>2</sub>, and PETCO<sub>2</sub> were 0.44 (95% confidence interval: 0.18–0.69) and 0.50 (0.18–0.74), respectively. After ARDS induction, mean CO, V̇CO<sub>2</sub>, PETCO<sub>2</sub>, and V<sub>d</sub>/V<sub>t</sub> were 3.33 (0.97) L/min, 113.71 (22.97) ml/min, 50.17 (9.73) mmHg and 0.40 (0.08). Partial correlations between CO and V̇CO<sub>2</sub> was 0.01 (−0.31 to 0.37) and between CO and PETCO<sub>2</sub> was 0.35 (−0.002 to 0.65).</p></div><div><h3>Conclusion</h3><p>ARDS may limit the utility of volumetric capnography to monitor CO.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2023-11-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1569904823001878\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1569904823001878","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Indirect cardiac output assessment in a swine pediatric acute respiratory distress syndrome model
Purpose
To investigate the correlation between volume of carbon dioxide elimination (V̇CO2) and end-tidal carbon dioxide (PETCO2) with cardiac output (CO) in a swine pediatric acute respiratory distress syndrome (ARDS) model.
Methods
Respiratory and hemodynamic variables were collected from twenty-six mechanically ventilated juvenile pigs under general anesthesia before and after inducing ARDS, using oleic acid infusion.
Results
Prior to ARDS induction, mean (SD) CO, V̇CO2, PETCO2, and dead space to tidal volume ratio (Vd/Vt) were 4.16 (1.10) L/min, 103.69 (18.06) ml/min, 40.72 (3.88) mmHg and 0.25 (0.09) respectively. Partial correlation coefficients between average CO, V̇CO2, and PETCO2 were 0.44 (95% confidence interval: 0.18–0.69) and 0.50 (0.18–0.74), respectively. After ARDS induction, mean CO, V̇CO2, PETCO2, and Vd/Vt were 3.33 (0.97) L/min, 113.71 (22.97) ml/min, 50.17 (9.73) mmHg and 0.40 (0.08). Partial correlations between CO and V̇CO2 was 0.01 (−0.31 to 0.37) and between CO and PETCO2 was 0.35 (−0.002 to 0.65).
Conclusion
ARDS may limit the utility of volumetric capnography to monitor CO.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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