抑郁症的孟德尔随机化研究:证据、机遇和挑战。

IF 3.6 3区 医学 Q1 PSYCHIATRY
Wang-Ran Ma, Lei-Lei Zhang, Jing-Ying Ma, Fang Yu, Ya-Qing Hou, Xiang-Rui Feng, Lin Yang
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引用次数: 0

摘要

背景:重度抑郁症(MDD)在世界范围内造成了重大的社会和经济负担。确定与重度抑郁症有因果关系的暴露、风险因素和生物学机制,有助于为疾病预防和开发新的治疗方法建立科学基础。方法:在本系统综述中,我们从孟德尔随机化(MR)研究中评估了推定的因果危险因素与重度抑郁症之间因果关系的证据。我们根据MR设计的关键要素评估方法学质量:使用完整的工具变量分析和三个关键MR假设的验证。结果:我们纳入了52篇文章的方法学细节和结果。磁共振研究支持生活方式、代谢、炎症生物标志物、特定病理状态和重度抑郁症之间的因果关系,尽管每种类型的结果差异很大。结论:虽然这篇综述显示MR可以为检查前瞻性治疗靶点和更好地理解重度抑郁症的病理生理提供有用的信息,但现有文献中一些方法学上的缺陷限制了结果的可靠性,并可能导致结果的异质性。我们强调了未来精神病学MR工作的观点和建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mendelian randomization studies of depression: evidence, opportunities, and challenges.

Background: Major depressive disorder (MDD) poses a significant social and economic burden worldwide. Identifying exposures, risk factors, and biological mechanisms that are causally connected to MDD can help build a scientific basis for disease prevention and development of novel therapeutic approaches.

Methods: In this systematic review, we assessed the evidence for causal relationships between putative causal risk factors and MDD from Mendelian randomization (MR) studies, following PRISMA. We assessed methodological quality based on key elements of the MR design: use of a full instrumental variable analysis and validation of the three key MR assumptions.

Results: We included methodological details and results from 52 articles. A causal link between lifestyle, metabolic, inflammatory biomarkers, particular pathological states and MDD is supported by MR investigations, although results for each category varied substantially.

Conclusions: While this review shows how MR can offer useful information for examining prospective treatment targets and better understanding the pathophysiology of MDD, some methodological flaws in the existing literature limit reliability of results and probably underlie their heterogeneity. We highlight perspectives and recommendations for future works on MR in psychiatry.

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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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