自体造血干细胞移植治疗难治性克罗恩病1例

Ana Gordo Ortega, Maren Eizaguirre Ubegun, Martín Balerdi Trébol, Saioa Rubio Iturria, Cristina Rodríguez Gutiérrez
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引用次数: 0

摘要

克罗恩病是一种慢性疾病,有时没有有效的药物或手术治疗。自体造血干细胞移植可能是这些患者恢复免疫耐受的一种治疗选择。因此,这可能导致疾病的缓解或降低其活性,使以前无效的药物变得有效。由于手术的安全性和它是非治愈性治疗的事实,患者的选择必须严格。我们报告我们在本中心选择的第一例自体造血干细胞移植患者的经验:27岁男性克罗恩病(A1L3B1p),多种药物治疗难治性,不适合手术治疗。移植两年后,患者仍无症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Autologous hematopoietic stem cell transplantation in a patient with refractory Crohn's disease].

Crohn's disease is a chronic condition for which sometimes there is no effective medical or surgical treatment. Autologous hematopoietic stem cell transplantation may be a therapeutic option for these patients to restore immune tolerance. Consequently, this may lead to remission of the disease or decrease its activity, making drugs that have previously failed be effective. Due to the safety profile of the procedure and the fact that it is a non-curative treatment, patient selection must be rigorous. We report our experience with the first patient selected in our centre for autologous hematopoietic stem cell transplantation: 27 years old male with Crohn's disease (A1L3B1p) refractory to multiple lines of medical treatment and not a candidate for surgical treatment. Two years after the transplantation, the patient remains asymptomatic.

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