Niloofar Daneshfar, Sara Falahi, Ali Gorgin Karaji, Alireza Rezaiemanesh, Seyed Hamid Reza Mortazavi, Bahman Akbari, Atefeh Eivazi, Farhad Salari
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引用次数: 0
摘要
化学引诱受体23 (ChemR23)在引发和解决急性炎症中起着至关重要的作用。本研究旨在评估chemR23基因的四个潜在功能snp (rs4373981 G > C、rs73201532 C > T、rs35121177 G > A和rs4964676 G > A)与变应性鼻炎(AR)易感性之间的关系。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法对130例变应性鼻炎患者和130例健康人进行基因分型。结果显示,两组患者的基因型及等位基因频率差异无统计学意义(p > 0.05)。此外,单倍型分析(分别为rs4373981、rs73201532和rs4964676)显示CTG、GTA和GTG单倍型对AR具有保护作用(p = 0.009、p = 0.0001、p = 0.001),而ChemR23多态性的CCG、GCA和GCG单倍型与AR风险增加相关(p = 0.03、p = 0.02、p = 0.0002)。这些发现提示ChemR23可能在AR的发病机制中起作用。
Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis.
The chemoattractant Receptor23 (ChemR23) plays an essential role in triggering and resolving acute inflammation. This study aimed to evaluate the association between four potentially functional SNPs of the chemR23 gene (rs4373981 G > C, rs73201532 C > T, rs35121177 G > A, and rs4964676 G > A) with susceptibility to Allergic rhinitis (AR). 130 patients with allergic rhinitis and 130 healthy individuals were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our findings showed that genotypes and alleles frequencies were not significantly different between patient and control groups (p > 0.05). Furthermore, haplotype analysis (rs4373981, rs73201532, and rs4964676, respectively) revealed a protective effect of CTG, GTA, and GTG haplotypes against AR (p = 0.009, p = 0.0001, p = 0.001, respectively), and CCG, GCA, and GCG haplotypes of ChemR23 polymorphisms were associated with increased risk of AR (p = 0.03, p = 0.02, p = 0.0002, respectively). These findings suggested a possible role for ChemR23 in the pathogenesis of AR.
期刊介绍:
Biochemical Genetics welcomes original manuscripts that address and test clear scientific hypotheses, are directed to a broad scientific audience, and clearly contribute to the advancement of the field through the use of sound sampling or experimental design, reliable analytical methodologies and robust statistical analyses.
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