肝细胞癌中胰岛素样生长因子-1受体(igf-1r)的免疫组织化学表达及其与临床病理参数的关系

IF 2.5 3区 医学 Q3 ONCOLOGY
Oncology Pub Date : 2024-01-01 Epub Date: 2023-11-21 DOI:10.1159/000535332
Maria Luiza Peloso Maia, Ronniel Morais Albuquerque, Serena Dafne do Carmo Silva, Cristiano Xavier Lima, Paulo Henrique Costa Diniz, Paula Vieira Teixeira Vidigal
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引用次数: 0

摘要

肝细胞癌(HCC)的癌变机制尚不完全清楚。胰岛素样生长因子-1受体(IGF-1R)可以转移到细胞核并调节细胞生长,可能参与HCC的发展和侵袭性。本研究旨在评估IGF-1R在HCC中的免疫表达及其与临床病理参数和临床结局的关系。方法:对111例在巴西转诊医院中心接受肝移植或部分手术切除的HCC患者的肝脏标本进行研究。免疫组化法检测IGF-1R表达,临床资料来源于病历,病理参数来源于路径回顾。结果:IGF-1R核表达在肿瘤中高于相邻肝硬化(p < 0.001)。在肝硬化中,IGF-1R在细胞核中的表达比在细胞膜中的表达要低,这表明从肝硬化到肿瘤,IGF-1R在细胞核中的表达比在细胞膜中的表达更普遍。肝细胞癌中IGF-1R核表达与组织学分化的中/差程度相关(p < 0.001)。然而,长期临床结果与IGF-1R核表达无关。结论:本研究数据提示IGF-1R在HCC进展和癌变中的作用,从肝硬化到肿瘤,IGF-1R在细胞核中的表达相对于膜的表达增加,并且与分化较差的肿瘤分级相关。进一步的研究有待于充分了解这种关联背后的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunohistochemical Expression of Insulin-Like Growth Factor-1 Receptor and Its Association with Clinicopathological Parameters in Hepatocellular Carcinoma.

Introduction: Hepatocellular carcinoma (HCC) carcinogenesis is not yet fully known. Insulin-like growth factor-1 receptor (IGF-1R) can translocate to the nucleus and modulate cellular growth, possibly participating in HCC development and aggressiveness. This study aimed to evaluate the immunoexpression of IGF-1R in HCC, the cellular compartment involved, and its association with clinicopathological parameters and clinical outcomes.

Methods: Liver specimens from 111 HCC patients who underwent liver transplantation or partial surgical resections at a Brazilian referral hospital center were studied. IGF-1R expression was determined by immunohistochemistry, clinical data were collected from medical records, and pathological parameters were obtained from path review.

Results: IGF-1R nuclear expression was higher in the tumor than in the adjacent cirrhosis (p < 0.001). The odds of IGF-1R expression in the nucleus compared to the membrane are lower in the cirrhosis condition than in the tumor, suggesting an increase in the prevalence of nucleus expression relative to the membrane from cirrhosis to tumor. There was an association between IGF-1R nuclear expression in HCC and the moderate/poor grade of histologic differentiation (p < 0.001). However, long-term clinical outcomes were not associated with IGF-1R nuclear expression.

Conclusion: The data presented here suggest the role of IGF-1R in HCC progression and carcinogenesis as its expression increases in the nucleus relative to the membrane, from cirrhosis to tumor, and it was associated with a poorer differentiated tumor grade. Further research is awaited to fully understand the mechanisms underlying this association.

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来源期刊
Oncology
Oncology 医学-肿瘤学
CiteScore
6.00
自引率
2.90%
发文量
76
审稿时长
6-12 weeks
期刊介绍: Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.
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