CD8+ t细胞在COVID-19中的应答特征

IF 8.4 2区医学 Q1 IMMUNOLOGY

Emerging Microbes & Infections Pub Date : 2024-12-01 Epub Date: 2024-01-11 DOI:10.1080/22221751.2023.2287118

Yuanting Yang, Heather Miller, Maria G Byazrova, Fabio Cndotti, Kamel Benlagha, Niels Olsen Saraiva Camara, Junming Shi, Huamei Forsman, Pamela Lee, Lu Yang, Alexander Filatov, Zhimin Zhai, Chaohong Liu

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引用次数: 0

摘要

本文综述了CD8+ T细胞在SARS-CoV-2感染中的保护作用。描述了未暴露队列中CD8+ T细胞介导的交叉反应反应。此外，本文还讨论了感染期间上呼吸道和下呼吸道驻留CD8+ T细胞的相关性，以及疫苗接种后CD8+ T细胞的反应，包括最近令人担忧的突破性感染和关注点变异(VOCs)。最后，我们解释了CD8+ T细胞与COVID-19严重程度之间的相关性。这一综述有助于更深入地理解CD8+ T细胞与SARS-CoV-2之间的关系，并为未来的探索拓宽了视野。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The characterization of CD8⁺ T-cell responses in COVID-19.

This review gives an overview of the protective role of CD8⁺ T cells in SARS-CoV-2 infection. The cross-reactive responses intermediated by CD8⁺ T cells in unexposed cohorts are described. Additionally, the relevance of resident CD8⁺ T cells in the upper and lower airway during infection and CD8⁺ T-cell responses following vaccination are discussed, including recent worrisome breakthrough infections and variants of concerns (VOCs). Lastly, we explain the correlation between CD8⁺ T cells and COVID-19 severity. This review aids in a deeper comprehension of the association between CD8⁺ T cells and SARS-CoV-2 and broadens a vision for future exploration.

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来源期刊

Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY

CiteScore

26.20

自引率

2.30%

发文量

276

审稿时长

20 weeks

期刊介绍： Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.