作为潜在抗炎药的芙蓉饮料中生物活性化合物的生物利用度。

Alejandro Arce-Reynoso, Raquel Mateos, Edgar J Mendivil, Víctor M Zamora-Gasga, S G Sáyago-Ayerdi
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引用次数: 0

摘要

采用有机酸(OA)和酚类化合物(PC)的体内生物利用度评价了芙蓉饮料(HbD)中生物活性化合物(BCs)的吸收和代谢。在人类中进行了急性单盲临床研究。12名志愿者饮用了HbD和对照饮料(CD)。在饮用这两种饮料后,采集了尿液和血浆样本。采用HPLC-DAD-MS对饮料(HbD和CD)和生物样品(尿液和血浆)的OA和PC进行了表征。在HbD和4个CD中检测到38个化合物,分别相当于937.37 mg / 60 mL和1.22 mg / 60 mL。两种饮料中木槿酸的OA含量最高。此外,在HbD中也检测到羟基肉桂酸、类黄酮、花青素和花青素,尽管它们的含量占总bc的10%。鉴定出25种不同的代谢物,15种在尿液中,23种在血浆中。微生物群广泛生物转化pc,其数量低于有机酸,特别是芙蓉酸和羟基柠檬酸。来自pc和有机酸的结肠代谢物可能是木槿具有抗炎生物活性的原因。然而,需要进一步的研究来评估其抗炎活性的代谢物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bioavailability of bioactive compounds in Hibiscus sabdariffa beverage as a potential anti-inflammatory.

The absorption and metabolism of bioactive compounds (BCs) in a Hibiscus sabdariffa drink (HbD) were evaluated by the in vivo bioavailability of organic acids (OA) and phenolic compounds (PC's). An acute single-blind clinical study in humans was conducted. Twelve volunteers consumed a HbD and a control drink (CD). Urine and plasma samples were taken after consuming both beverages. OA and PC's of the beverages (HbD and CD) and the biological samples (urine and plasma) were characterized by HPLC-DAD-MS. Thirthy-eight compounds in HbD and four CD were detected and quantified, equivalent to 937.37 mg and 1.22 mg per 60 mL, respectively. Hibiscus acid was the most abundant OA in both drinks. Additionally, hydroxycinnamic acids, flavonoids, anthocyanins, and anthocyanidins were also detected in HbD, although their amount represented 10% of the total BCs. 25 different metabolites were identified, 15 in urine and 23 in plasma. The microbiota extensively biotransformed PCs and their amount was lower than organic acids, particularly hibiscus acid and hydroxycitric acid. The colonic metabolites derived from PCs and organic acids would be behind the anti-inflammatory bioactivity described for Hibiscus sabdariffa L. (Malvaceae family). However, further studies are necessary to evaluate the metabolites responsible for their anti-inflammatory activity.

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