Jorge Ligero-López , Eduardo Rubio-Mora , Mario David Ruiz-Bastián , María Inmaculada Quiles-Melero , Juana Cacho-Calvo , Emilio Cendejas-Bueno
{"title":"某三级医院引起菌血症的厌氧菌药敏试验:一项为期13年(2010-2022)的回顾性研究。","authors":"Jorge Ligero-López , Eduardo Rubio-Mora , Mario David Ruiz-Bastián , María Inmaculada Quiles-Melero , Juana Cacho-Calvo , Emilio Cendejas-Bueno","doi":"10.1016/j.anaerobe.2023.102803","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Infections from anaerobic microorganisms result from breached mucosal barriers, posing a significant mortality risk. A retrospective study at Hospital Universitario La Paz (Madrid) from 2010 to 2022 analyzed 491 (6.17 %) anaerobic </span>bacteremia cases out of 7956 significant bacteremia cases among 171,833 blood culture requests. </span><span><em>Bacteroides fragilis</em></span> was the most frequently isolated species (28.3 %), followed by <span><em>Clostridium perfringens</em></span> (13.6 %). <em>B. fragilis</em><span> showed good susceptibility to amoxicillin/ clavulanic acid (86 %), piperacillin/tazobactam (86 %), and metronidazole (87.7 %). In general, non-</span><em>fragilis Bacteroides</em><span><span> species showed low susceptibility to penicillin<span> (7 %), amoxicillin (17.5 %), and </span></span>clindamycin (64.9 %). Of our 13 </span><em>non-perfringens Clostridium</em> isolates, four exhibited resistance to penicillin and four showed resistance to clindamycin. <span><em>Lactobacillus</em></span> species were highly susceptible to antibiotics tested. <span><em>Prevotella</em></span><span> spp. showed low susceptibility to penicillin (20 %), amoxicillin (20 %), and clindamycin (40 %). The study contributes valuable data for monitoring and improving anaerobic bacteremia treatment.</span></p></div>","PeriodicalId":8050,"journal":{"name":"Anaerobe","volume":"84 ","pages":"Article 102803"},"PeriodicalIF":2.5000,"publicationDate":"2023-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial susceptibility testing of anaerobic bacteria causing bacteremia: A 13-year (2010–2022) retrospective study in a tertiary hospital\",\"authors\":\"Jorge Ligero-López , Eduardo Rubio-Mora , Mario David Ruiz-Bastián , María Inmaculada Quiles-Melero , Juana Cacho-Calvo , Emilio Cendejas-Bueno\",\"doi\":\"10.1016/j.anaerobe.2023.102803\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Infections from anaerobic microorganisms result from breached mucosal barriers, posing a significant mortality risk. A retrospective study at Hospital Universitario La Paz (Madrid) from 2010 to 2022 analyzed 491 (6.17 %) anaerobic </span>bacteremia cases out of 7956 significant bacteremia cases among 171,833 blood culture requests. </span><span><em>Bacteroides fragilis</em></span> was the most frequently isolated species (28.3 %), followed by <span><em>Clostridium perfringens</em></span> (13.6 %). <em>B. fragilis</em><span> showed good susceptibility to amoxicillin/ clavulanic acid (86 %), piperacillin/tazobactam (86 %), and metronidazole (87.7 %). In general, non-</span><em>fragilis Bacteroides</em><span><span> species showed low susceptibility to penicillin<span> (7 %), amoxicillin (17.5 %), and </span></span>clindamycin (64.9 %). Of our 13 </span><em>non-perfringens Clostridium</em> isolates, four exhibited resistance to penicillin and four showed resistance to clindamycin. <span><em>Lactobacillus</em></span> species were highly susceptible to antibiotics tested. <span><em>Prevotella</em></span><span> spp. showed low susceptibility to penicillin (20 %), amoxicillin (20 %), and clindamycin (40 %). The study contributes valuable data for monitoring and improving anaerobic bacteremia treatment.</span></p></div>\",\"PeriodicalId\":8050,\"journal\":{\"name\":\"Anaerobe\",\"volume\":\"84 \",\"pages\":\"Article 102803\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-11-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anaerobe\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1075996423001166\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anaerobe","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1075996423001166","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Antimicrobial susceptibility testing of anaerobic bacteria causing bacteremia: A 13-year (2010–2022) retrospective study in a tertiary hospital
Infections from anaerobic microorganisms result from breached mucosal barriers, posing a significant mortality risk. A retrospective study at Hospital Universitario La Paz (Madrid) from 2010 to 2022 analyzed 491 (6.17 %) anaerobic bacteremia cases out of 7956 significant bacteremia cases among 171,833 blood culture requests. Bacteroides fragilis was the most frequently isolated species (28.3 %), followed by Clostridium perfringens (13.6 %). B. fragilis showed good susceptibility to amoxicillin/ clavulanic acid (86 %), piperacillin/tazobactam (86 %), and metronidazole (87.7 %). In general, non-fragilis Bacteroides species showed low susceptibility to penicillin (7 %), amoxicillin (17.5 %), and clindamycin (64.9 %). Of our 13 non-perfringens Clostridium isolates, four exhibited resistance to penicillin and four showed resistance to clindamycin. Lactobacillus species were highly susceptible to antibiotics tested. Prevotella spp. showed low susceptibility to penicillin (20 %), amoxicillin (20 %), and clindamycin (40 %). The study contributes valuable data for monitoring and improving anaerobic bacteremia treatment.
期刊介绍：
Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes.
Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.
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