Jan René Nkeck , Claudine Jessica Yondo Ndedi , Liliane Mfeukeu Kuate , Annick Ndoumba Mintya , Marie Ida Chemgne , Joachim Tchikapa , Larissa Ange Tchuisseu Kwangoua , Charelle Boukeu Yonta , Corine Zouague Zalbi , Andrée Ntyam Abena , Falmata Amazia , Vicky Jocelyne Ama Moor
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However, usefulness of leukocyte ratios in cardiovascular risk (CVR) assessment hasn't yet been proven in Cameroonians.</p></div><div><h3>Objective</h3><p>Evaluate the contribution of leukocyte ratios in CVR assessment of non-diabetic hypertensive adults.</p></div><div><h3>Methodology</h3><p>We carried out a cross sectional study including non-diabetic hypertensive patients followed up at the cardiology unit of the Yaoundé Central Hospital from November to June 2022. We collected relevant clinical data with a pre-established questionnaire and blood samples from each patient for different biological analyses. The spearman correlation test was used to assess on the one hand the relationship between leukocyte ratios, highly sensitive CRP and the WHO 2019 risk score as our primary end point, and on the other hand between leukocyte indices and the other risk estimators as our secondary outcome. The significant threshold level was set as 0.05.</p></div><div><h3>Results</h3><p>We included 165 participants (102 females) with a mean age of 57.6 (10.4) years. The median duration of hypertension since diagnosis was 7 years and only 27% of participants on treatment had a controlled blood pressure. There was no significant correlation between leukocyte ratios and the WHO 2019 risk score. Highly sensitive CRP and the atherogenic index of plasma were significantly correlated respectively with the granulocyte to lymphocyte ratio (rho = 0.18, <em>p</em> = 0.03) and the eosinophil to lymphocyte ratio (rho = 0.28, <em>p</em> = 0.01). There exists a weak positive association between the granulocyte to lymphocyte ratio and the Reynolds risk score.</p></div><div><h3>Conclusion</h3><p>Leukocyte ratios are not useful for CVR assessment in hypertensive Cameroonians with respect to the WHO 2019 risk score. 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引用次数: 0
摘要
背景:全血细胞计数是评估高血压患者的常规方法。然而，白细胞比率在心血管风险(CVR)评估中的有用性尚未在喀麦隆人中得到证实。目的:探讨白细胞比率在非糖尿病性高血压成人CVR评估中的作用。方法:我们对2022年11月至6月在雅温得中心医院心内科随访的非糖尿病性高血压患者进行了横断面研究。我们通过预先制定的问卷和每位患者的血液样本收集相关临床数据，进行不同的生物学分析。我们使用spearman相关检验，一方面评估白细胞比率、高敏感CRP与WHO 2019风险评分之间的关系，作为我们的主要终点，另一方面评估白细胞指数与其他风险评估指标之间的关系，作为我们的次要结局。显著性阈值水平设为0.05。结果:我们纳入165名参与者(102名女性)，平均年龄57.6(10.4)岁。自诊断以来高血压的中位持续时间为7年，只有27%的治疗参与者血压得到控制。白细胞比率与世卫组织2019年风险评分之间没有显著相关性。血浆高敏CRP和动脉粥样硬化指数分别与粒细胞/淋巴细胞比值(rho = 0.18, p = 0.03)和嗜酸性粒细胞/淋巴细胞比值(rho = 0.28, p = 0.01)呈显著相关。粒细胞/淋巴细胞比值与雷诺兹风险评分呈弱正相关。结论:与WHO 2019风险评分相比，白细胞比率对喀麦隆高血压患者的CVR评估没有帮助。需要前瞻性研究来评估它们与传统危险因素结合的有效性，以改善心血管事件的预测。
Leukocyte ratios in non-diabetic hypertensive Cameroonians do not predict cardiovascular risk : preliminary results of the HYRICCA project
Background
Full blood count is routinely performed in the evaluation of hypertensive patients. However, usefulness of leukocyte ratios in cardiovascular risk (CVR) assessment hasn't yet been proven in Cameroonians.
Objective
Evaluate the contribution of leukocyte ratios in CVR assessment of non-diabetic hypertensive adults.
Methodology
We carried out a cross sectional study including non-diabetic hypertensive patients followed up at the cardiology unit of the Yaoundé Central Hospital from November to June 2022. We collected relevant clinical data with a pre-established questionnaire and blood samples from each patient for different biological analyses. The spearman correlation test was used to assess on the one hand the relationship between leukocyte ratios, highly sensitive CRP and the WHO 2019 risk score as our primary end point, and on the other hand between leukocyte indices and the other risk estimators as our secondary outcome. The significant threshold level was set as 0.05.
Results
We included 165 participants (102 females) with a mean age of 57.6 (10.4) years. The median duration of hypertension since diagnosis was 7 years and only 27% of participants on treatment had a controlled blood pressure. There was no significant correlation between leukocyte ratios and the WHO 2019 risk score. Highly sensitive CRP and the atherogenic index of plasma were significantly correlated respectively with the granulocyte to lymphocyte ratio (rho = 0.18, p = 0.03) and the eosinophil to lymphocyte ratio (rho = 0.28, p = 0.01). There exists a weak positive association between the granulocyte to lymphocyte ratio and the Reynolds risk score.
Conclusion
Leukocyte ratios are not useful for CVR assessment in hypertensive Cameroonians with respect to the WHO 2019 risk score. Prospective studies are needed to assess their usefulness in combination with conventional risk factors to improve prediction of cardiovascular events.
期刊介绍：
Organe scientifique de référence fondé en 1951, les Annales de cardiologie et d''angéiologie abordent tous les domaines qui intéressent quotidiennement les cardiologues et les angéiologues praticiens : neurologie et radiologie vasculaires, hémostase, diabétologie, médecine interne, épidémiologie et prévention.
Les Annales de cardiologie et d''angéiologie sont indexées aux grandes bases de données et publient rapidement, et en conformité avec les normes internationales de publication scientifique, des articles en français sur la pathologie cardiaque.
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