M T Portolés, R Pagani, M J Ainaga, I Díaz-Laviada, A M Municio
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Lipopolysaccharide-induced insulin resistance in monolayers of cultured hepatocytes.
In order to clarify the endotoxin effect on the hepatic removal of insulin, the influence of lipopolysaccharide (LPS) from E. coli 0111:B4 on the insulin binding and endocytosis in cultured hepatocytes from adult male rats has been investigated. LPS decreases both processes in a time and temperature-dependent manner, showing a major effect at short time and low temperature, according to the characteristics of LPS binding and uptake.
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