¿Influyen los trastornos del ánimo en el control de crisis de pacientes con epilepsia?

Objectives

To study the prevalence of mood disorders in patients with epilepsy and their relationship with seizure control.

Methods

We conducted an observational and cross-sectional study of epileptic patients treated in our centre from January-2017 to June-2019. We classify patients into 2 groups according to crisis control: good control (≤1 crisis / month) and poor control (> 1 crisis / month) and we compare the demographic variables (age, sex, employment status and civil status), clinics (epilepsy type, crisis type, years of evolution of epilepsy), therapeutic (antiepileptic, antidepressant and anxiolytic drugs), presence of depression (NDDI-E scale), anxiety (GAD7 scale) and quality of life (QOLIE10). The data was collected by doctors and nurses after informed consent was signed.

Results

152 patients participated, 53% were men with a mean age of 44 ± 11 years. Sixty-eight percent (n = 103) had good crisis control and 32% (n = 49) poor control. Thirty-six point 6 percent had depression (NDDI-E> 15) and 42% anxiety (GAD> 10). Sixty percent of patients with depression and 54% with anxiety did not receive antidepressant and / or anxiolytic treatment. The factors associated with poor crisis control were the presence of depression (OR 2.3, P=.02) and a worse quality of life (OR 1.8, P=.01).

Conclusions

The presence of altered mood in patients with epilepsy is frequent. In our series, depression and a worse quality of life were related to worse crisis control.