{"title":"利用一对多尿液蛋白质组比较为不明原因发热提供线索","authors":"Chenyang Zhao , Lilong Wei , Jing Wei , Yun Zhou , Youhe Gao , Yongtong Cao","doi":"10.1016/j.urine.2022.10.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To provide diagnostic evidence and clues for patients with fever of unknown origin (FUO) through urine proteomics analysis.</p></div><div><h3>Methods</h3><p>Urine samples of FUO were one–to–many analysed by using liquid chromatography tandem mass spectrometry(LC–MS/MS) to identify differential proteins and related biological pathways. One–to–many analysis means a comparative analysis of one sample to many controls.</p></div><div><h3>Results</h3><p>We observed biological pathways related to fever, such as LXR/RXR activation, FXR/RXR activation and acute phase response signaling, etc., which indicates that urine can obviously distinguish disease from health status. In addition, we found that the results of each sample were different, which highlight the necessity of one–to–many analysis.</p></div><div><h3>Conclusions</h3><p>The combined method of urine proteomics and one–to–many analysis can provide clues for FUO, and might also be applied to the exploration of any unknown disease. In addition to providing information on diagnostic markers of diseases, urine may also provide mechanisms of diseases and related therapeutic targets.</p></div>","PeriodicalId":75287,"journal":{"name":"Urine (Amsterdam, Netherlands)","volume":"4 ","pages":"Pages 32-42"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590280622000080/pdfft?md5=46d13bc538ceca901caeec12edd4aac6&pid=1-s2.0-S2590280622000080-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Using one-to-many urine proteome comparisons to provide clues for fever of unknown origin\",\"authors\":\"Chenyang Zhao , Lilong Wei , Jing Wei , Yun Zhou , Youhe Gao , Yongtong Cao\",\"doi\":\"10.1016/j.urine.2022.10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To provide diagnostic evidence and clues for patients with fever of unknown origin (FUO) through urine proteomics analysis.</p></div><div><h3>Methods</h3><p>Urine samples of FUO were one–to–many analysed by using liquid chromatography tandem mass spectrometry(LC–MS/MS) to identify differential proteins and related biological pathways. One–to–many analysis means a comparative analysis of one sample to many controls.</p></div><div><h3>Results</h3><p>We observed biological pathways related to fever, such as LXR/RXR activation, FXR/RXR activation and acute phase response signaling, etc., which indicates that urine can obviously distinguish disease from health status. In addition, we found that the results of each sample were different, which highlight the necessity of one–to–many analysis.</p></div><div><h3>Conclusions</h3><p>The combined method of urine proteomics and one–to–many analysis can provide clues for FUO, and might also be applied to the exploration of any unknown disease. In addition to providing information on diagnostic markers of diseases, urine may also provide mechanisms of diseases and related therapeutic targets.</p></div>\",\"PeriodicalId\":75287,\"journal\":{\"name\":\"Urine (Amsterdam, Netherlands)\",\"volume\":\"4 \",\"pages\":\"Pages 32-42\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2590280622000080/pdfft?md5=46d13bc538ceca901caeec12edd4aac6&pid=1-s2.0-S2590280622000080-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Urine (Amsterdam, Netherlands)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590280622000080\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urine (Amsterdam, Netherlands)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590280622000080","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Using one-to-many urine proteome comparisons to provide clues for fever of unknown origin
Objective
To provide diagnostic evidence and clues for patients with fever of unknown origin (FUO) through urine proteomics analysis.
Methods
Urine samples of FUO were one–to–many analysed by using liquid chromatography tandem mass spectrometry(LC–MS/MS) to identify differential proteins and related biological pathways. One–to–many analysis means a comparative analysis of one sample to many controls.
Results
We observed biological pathways related to fever, such as LXR/RXR activation, FXR/RXR activation and acute phase response signaling, etc., which indicates that urine can obviously distinguish disease from health status. In addition, we found that the results of each sample were different, which highlight the necessity of one–to–many analysis.
Conclusions
The combined method of urine proteomics and one–to–many analysis can provide clues for FUO, and might also be applied to the exploration of any unknown disease. In addition to providing information on diagnostic markers of diseases, urine may also provide mechanisms of diseases and related therapeutic targets.
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