{"title":"5-羟色胺受体5-HT1A和5-羟色胺转运体5-HTTLPR的多态性变异与不良妊娠结局:一项初步研究","authors":"Hamutal Taube , Aharon Tevet , Gheona Altarescu , Arnon Samueloff , Sorina Grisaru-Granovsky","doi":"10.1016/j.jrhm.2015.06.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background/aims</h3><p><span>Antenatal depression<span> may have adverse effects on pregnancy outcomes such as preterm birth (PTB) and small-for-gestational-age neonates. Serotonin as a </span></span>neurotransmitter<span> is intimately related to stress and depression. The purpose of this study was to assess variants of the serotonin receptor (5-HT1A) gene and serotonin transporter promoter (5-HTTLPR) gene as potentially directly involved in adverse pregnancy outcomes (APOs), especially PTB.</span></p></div><div><h3>Methods</h3><p>A pilot case-control study over two years identifying 78 women delivered at <35 weeks gestational age (PTB) and 265 women with uncomplicated singleton term delivery who were evaluated for APO and early pregnancy<span> loss (EPL) in a division for maternal and fetal medicine in a single tertiary center.</span></p></div><div><h3>Results</h3><p>Women with the <em>s/s</em> serotonin transporter 5-HTTLPR genotype experienced significantly more EPLs but there was no significant association between serotonin polymorphisms and preterm birth.</p></div><div><h3>Conclusion</h3><p><span>Two serotonin gene polymorphisms, known to be associated with depression, are hereby shown to be associated with APO. EPL, but not preterm birth, is significantly linked to an </span><em>s/s</em> serotonin transporter 5-HTTLPR genotype.</p></div>","PeriodicalId":91915,"journal":{"name":"Journal of reproductive health and medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jrhm.2015.06.004","citationCount":"0","resultStr":"{\"title\":\"Polymorphic variants of the serotonin receptor, 5-HT1A, and the serotonin transporter, 5-HTTLPR, and adverse pregnancy outcomes: A pilot study\",\"authors\":\"Hamutal Taube , Aharon Tevet , Gheona Altarescu , Arnon Samueloff , Sorina Grisaru-Granovsky\",\"doi\":\"10.1016/j.jrhm.2015.06.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background/aims</h3><p><span>Antenatal depression<span> may have adverse effects on pregnancy outcomes such as preterm birth (PTB) and small-for-gestational-age neonates. Serotonin as a </span></span>neurotransmitter<span> is intimately related to stress and depression. The purpose of this study was to assess variants of the serotonin receptor (5-HT1A) gene and serotonin transporter promoter (5-HTTLPR) gene as potentially directly involved in adverse pregnancy outcomes (APOs), especially PTB.</span></p></div><div><h3>Methods</h3><p>A pilot case-control study over two years identifying 78 women delivered at <35 weeks gestational age (PTB) and 265 women with uncomplicated singleton term delivery who were evaluated for APO and early pregnancy<span> loss (EPL) in a division for maternal and fetal medicine in a single tertiary center.</span></p></div><div><h3>Results</h3><p>Women with the <em>s/s</em> serotonin transporter 5-HTTLPR genotype experienced significantly more EPLs but there was no significant association between serotonin polymorphisms and preterm birth.</p></div><div><h3>Conclusion</h3><p><span>Two serotonin gene polymorphisms, known to be associated with depression, are hereby shown to be associated with APO. EPL, but not preterm birth, is significantly linked to an </span><em>s/s</em> serotonin transporter 5-HTTLPR genotype.</p></div>\",\"PeriodicalId\":91915,\"journal\":{\"name\":\"Journal of reproductive health and medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jrhm.2015.06.004\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of reproductive health and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214420X1500025X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of reproductive health and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214420X1500025X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Polymorphic variants of the serotonin receptor, 5-HT1A, and the serotonin transporter, 5-HTTLPR, and adverse pregnancy outcomes: A pilot study
Background/aims
Antenatal depression may have adverse effects on pregnancy outcomes such as preterm birth (PTB) and small-for-gestational-age neonates. Serotonin as a neurotransmitter is intimately related to stress and depression. The purpose of this study was to assess variants of the serotonin receptor (5-HT1A) gene and serotonin transporter promoter (5-HTTLPR) gene as potentially directly involved in adverse pregnancy outcomes (APOs), especially PTB.
Methods
A pilot case-control study over two years identifying 78 women delivered at <35 weeks gestational age (PTB) and 265 women with uncomplicated singleton term delivery who were evaluated for APO and early pregnancy loss (EPL) in a division for maternal and fetal medicine in a single tertiary center.
Results
Women with the s/s serotonin transporter 5-HTTLPR genotype experienced significantly more EPLs but there was no significant association between serotonin polymorphisms and preterm birth.
Conclusion
Two serotonin gene polymorphisms, known to be associated with depression, are hereby shown to be associated with APO. EPL, but not preterm birth, is significantly linked to an s/s serotonin transporter 5-HTTLPR genotype.