新生儿败血症管理的挑战

Renato Soibelmann Procianoy, Rita C. Silveira
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引用次数: 0

摘要

目的介绍新生儿早期和晚期脓毒症的病因、危险因素、诊断和治疗的最新证据。数据来源:对Medline (PubMed)、Scopus、Web of Science、Cochrane和谷歌Scholar数据库进行系统综述,涉及以下术语:新生儿败血症、早期新生儿败血症、晚期新生儿败血症、经验抗生素治疗、败血症计算器、万古霉素、新生儿、早产儿。新生儿脓毒症是新生儿发病和死亡的常见原因。它的诊断很困难。对病人的持续观察是诊断怀疑的关键。当怀疑新生儿败血症时,应进行细菌学检查。万古霉素不应常规应用于晚期新生儿败血症的经验性抗生素治疗方案中,预防新生儿败血症的主要保护机制是洗手和使用母乳。结论新生儿是脓毒症易感人群。了解危险因素和病因可以更好地处理新生儿败血症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The challenges of neonatal sepsis management

Objectives

To present current evidence on the etiology, risk factors, diagnosis, and management of early and late neonatal sepsis.

Source of data

Non‐systematic review of the Medline (PubMed), Scopus, Web of Science, Cochrane, and Google Scholar databases regarding the following terms: neonatal sepsis, early neonatal sepsis, late neonatal sepsis, empirical antibiotic therapy, sepsis calculator, vancomycin, newborn, preterm newborn.

Data synthesis

Neonatal sepsis is a frequent cause of neonatal morbidity and mortality. Its diagnosis is difficult. Continuous observation of the patient is critical to diagnostic suspicion. When neonatal sepsis is suspected, bacteriological tests should be collected. Vancomycin should not be routinely using in the empirical antibiotic regimen in late neonatal sepsis, and the main protective mechanisms against neonatal sepsis are handwashing and the use of breast milk.

Conclusions

Newborns constitute a group that is more vulnerable to sepsis. Knowledge of risk factors and etiological agents allows a better approach to the newborn with sepsis.

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