慢性缺氧和维拉帕米对组织和血浆cAMP含量的影响。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01

X J Yuan, Y N Cai

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引用次数: 0

摘要

测定和研究了慢性缺氧和维拉帕米对大鼠肺、心、主动脉组织及血浆cAMP含量的影响。结果表明，慢性缺氧(15 d)使大鼠血浆、肺和心肌组织cAMP含量明显升高。维拉帕米是一种钙激动剂，可降低血浆和肺cAMP含量的升高，但不影响心肌cAMP含量。这表明钙的流入是cAMP含量增加的原因。

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Effects of chronic hypoxia and verapamil on cAMP content in tissues and blood plasma.

Changes in cAMP content of tissues of lung, heart and aorta and in blood plasma of rats during chronic hypoxia and administration of verapamil were determined and investigated. The results showed that chronic hypoxia (15 days) obviously increased cAMP content of blood plasma, lung and myocardiac tissues. Verapamil, a calcium agonist, attenuated the increase of cAMP content in blood plasma and lung but did not affect cAMP content of the myocardium. It is suggested that a calcium influx is responsible for the increase in cAMP content.

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Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao

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