Thusharika Dissanayaka , Piumi Nakandala , Kavinda Malwanage , Aron T. Hill , Deborah N. Ashthree , Melissa M. Lane , Nikolaj Travicia , Elizabeth Gamage , Wolfgang Marx , Shapour Jaberzadeh
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We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) −0.52; 95% CI, −0.78 to −0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD −1.23; 95% CI, −1.59 to −0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision.</p></div><div><h3>Discussion and Conclusion</h3><p>A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings.</p></div><div><h3>Significance</h3><p>A-tDCS can be used as a standalone and adjunct treatment for KOA.</p></div><div><h3>Study registration</h3><p>PROSPERO number CRD42021255114</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102921"},"PeriodicalIF":2.7000,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705323000783/pdfft?md5=d74ed43e772b7e90a1592563c166f12a&pid=1-s2.0-S0987705323000783-main.pdf","citationCount":"1","resultStr":"{\"title\":\"The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis\",\"authors\":\"Thusharika Dissanayaka , Piumi Nakandala , Kavinda Malwanage , Aron T. 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The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis
Objectives
To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA).
Methods
The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement.
Results
Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) −0.52; 95% CI, −0.78 to −0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD −1.23; 95% CI, −1.59 to −0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision.
Discussion and Conclusion
A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings.
Significance
A-tDCS can be used as a standalone and adjunct treatment for KOA.
期刊介绍：
Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.
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