基于张量的DTI配准对本质上非常低对比度的脑磁共振图像进行分割

Q4 Neuroscience
M.L. Al-Saady , N.I. Wolf , P.J.W. Pouwels
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引用次数: 2

摘要

背景:对于低髓鞘性脑白质营养不良患者,由于缺乏髓鞘,t1加权脑MRI对比度非常低,无法进行可靠的分割。在扩散张量图像中,由于白质束的各向异性和取向,对比度更高。我们的目标是开发和评估一种基于张量引导的基于图集的分割方法,适用于非常低对比度图像的分割。方法选取17例对照组(平均年龄8.0岁(SD 8.0))和27例低髓鞘性脑白质营养不良患者(平均年龄10.7岁(SD 10.2))。采用DTI- tk张量引导的基于iit图谱的分割方法对DTI和3D T1图像进行分割。对于对照组,将这些分割与3D t1加权图像的常规分割进行比较。使用DTI指标进行定性视觉评估和定量评估,以评估患者分割。结果在对照受试者中,基于张量的方法与基于图谱的分割方法效果一致,对皮质灰质(GM)、WM、深部灰质(DGM)和丘脑的Dice系数分别为0.65、0.72、0.81和0.86。在髓鞘发育低下的患者中,视觉评估显示解剖上足够的节段。所有组织特异性DTI指标在患者和对照组之间都存在差异。髓鞘化程度低的患者不仅在总WM中,而且在皮质脊髓束、视神经束和丘脑中,FA降低,平均、轴向和径向弥散性增加。结论即使在没有正常髓磷脂的情况下,轴突的存在和方向也允许基于张量的配准,从而实现基于图谱的分割。我们展示了在定量MRI背景下分割方法的适用性,允许对非常低对比度的图像进行全脑或区域组织特异性和通道特异性分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Segmentation of intrinsically very low contrast magnetic resonance brain images using tensor-based DTI registration

Background

In patients with hypomyelinating leukodystrophies, contrast of T1-weighted brain MRI is very low due to the lack of myelin, preventing a reliable segmentation. In diffusion tensor images the contrast is higher, thanks to anisotropy and orientation of white matter (WM) tracts. We aimed to develop and assess a tensor-guided atlas-based segmentation method suitable for segmentation of very low contrast images.

Methods

17 control subjects (mean age 8.0 yrs (SD 8.0)) and 27 subjects with hypomyelinating leukodystrophies (mean age 10.7 yrs (SD 10.2)) were included. DTI and 3D T1 images were segmented using a DTI-TK tensor-guided IIT-atlas-based segmentation method. For the control subjects, these segmentations were compared with a conventional segmentation of their 3D T1-weighted images. A qualitative visual assessment and a quantitative assessment using DTI metrics was performed to assess the patient segmentations.

Results

In control subjects, the tensor-based method performed as can be expected for atlas-based segmentation methods, with Dice coefficients of 0.65, 0.72, 0.81 and 0.86 for cortical grey matter (GM), WM, deep grey matter (DGM), and thalamus, respectively. In patients with hypomyelination the visual assessment showed anatomically adequate segmentations. All tissue-specific DTI metrics differed between patients and controls. Patients with hypomyelination had reduced FA and increased mean, axial and radial diffusivities, not only in total WM, but also in the corticospinal tracts, optic radiations and thalamus.

Conclusion

Even in the absence of normal myelin, the presence and direction of axons allowed tensor-based registration and thereby atlas-based segmentation. We showed the applicability of the segmentation method in the context of quantitative MRI, allowing for whole-brain or regional tissue-specific and tract-specific analyses of very low contrast images.

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来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
自引率
0.00%
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审稿时长
87 days
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