消极情绪降低了腹内侧前额叶皮层对奖励结果的辨别能力。

Lakshman N C Chakravarthula, Srikanth Padmala
{"title":"消极情绪降低了腹内侧前额叶皮层对奖励结果的辨别能力。","authors":"Lakshman N C Chakravarthula, Srikanth Padmala","doi":"10.1093/scan/nsad067","DOIUrl":null,"url":null,"abstract":"<p><p>Reward and emotion are tightly intertwined, so there is a growing interest in mapping their interactions. However, our knowledge of these interactions in the human brain, especially during the consummatory phase of reward is limited. To address this critical gap, we conducted a functional magnetic resonance imaging study to investigate the effects of negative emotion on reward outcome processing. We employed a novel design where emotional valence (negative or neutral) indicated the type of outcome (reward or no-reward) in a choice task. We focused our functional magnetic resonance imaging analysis on the ventro-medial prefrontal cortex (vmPFC), ventral striatum and amygdala, which were frequently implicated in reward outcome processing. In these regions of interest, we performed multi-voxel pattern analysis to specifically probe how negative emotion modulates reward outcome processing. In vmPFC, using decoding analysis, we found evidence consistent with the reduced discriminability of multi-variate activity patterns of reward vs no-reward outcomes when signaled by a negative relative to a neutral image, suggesting an emotional modulation of reward processing along the plausible common value/valence dimension. These findings advance our limited understanding of the basic brain mechanisms underlying the influence of negative emotion on consummatory reward processing, with potential implications for mental disorders, particularly anxiety and depression.</p>","PeriodicalId":94208,"journal":{"name":"Social cognitive and affective neuroscience","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661064/pdf/","citationCount":"0","resultStr":"{\"title\":\"Negative emotion reduces the discriminability of reward outcomes in the ventromedial prefrontal cortex.\",\"authors\":\"Lakshman N C Chakravarthula, Srikanth Padmala\",\"doi\":\"10.1093/scan/nsad067\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Reward and emotion are tightly intertwined, so there is a growing interest in mapping their interactions. However, our knowledge of these interactions in the human brain, especially during the consummatory phase of reward is limited. To address this critical gap, we conducted a functional magnetic resonance imaging study to investigate the effects of negative emotion on reward outcome processing. We employed a novel design where emotional valence (negative or neutral) indicated the type of outcome (reward or no-reward) in a choice task. We focused our functional magnetic resonance imaging analysis on the ventro-medial prefrontal cortex (vmPFC), ventral striatum and amygdala, which were frequently implicated in reward outcome processing. In these regions of interest, we performed multi-voxel pattern analysis to specifically probe how negative emotion modulates reward outcome processing. In vmPFC, using decoding analysis, we found evidence consistent with the reduced discriminability of multi-variate activity patterns of reward vs no-reward outcomes when signaled by a negative relative to a neutral image, suggesting an emotional modulation of reward processing along the plausible common value/valence dimension. These findings advance our limited understanding of the basic brain mechanisms underlying the influence of negative emotion on consummatory reward processing, with potential implications for mental disorders, particularly anxiety and depression.</p>\",\"PeriodicalId\":94208,\"journal\":{\"name\":\"Social cognitive and affective neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661064/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Social cognitive and affective neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/scan/nsad067\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Social cognitive and affective neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/scan/nsad067","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

奖励和情感是紧密交织在一起的,所以人们对绘制它们之间的相互作用越来越感兴趣。然而,我们对人类大脑中这些相互作用的了解,特别是在奖励的完善阶段是有限的。为了解决这一关键的差距,我们进行了功能性MRI研究,以调查负面情绪对奖励结果处理的影响。我们采用了一种新颖的设计,在这种设计中,情绪效价(消极或中性)表明了选择任务的结果类型(奖励或无奖励)。我们将fMRI分析集中在腹内侧前额叶皮层(vmPFC)、腹侧纹状体和杏仁核上,这些区域经常与奖励结果处理有关。在这些感兴趣的区域,我们进行了多体素模式分析(MVPA)来具体探讨负面情绪如何调节奖励结果处理。在vmPFC中,通过解码分析,我们发现了与以下证据相一致的证据:当相对于中性图像发出消极信号时,奖励与无奖励结果的多变量活动模式的可区别性降低,这表明在合理的共同价值/效价维度上,奖励加工存在情绪调节。这些发现促进了我们对消极情绪影响完满性奖励处理的基本大脑机制的有限理解,并对精神障碍,特别是焦虑和抑郁具有潜在的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Negative emotion reduces the discriminability of reward outcomes in the ventromedial prefrontal cortex.

Reward and emotion are tightly intertwined, so there is a growing interest in mapping their interactions. However, our knowledge of these interactions in the human brain, especially during the consummatory phase of reward is limited. To address this critical gap, we conducted a functional magnetic resonance imaging study to investigate the effects of negative emotion on reward outcome processing. We employed a novel design where emotional valence (negative or neutral) indicated the type of outcome (reward or no-reward) in a choice task. We focused our functional magnetic resonance imaging analysis on the ventro-medial prefrontal cortex (vmPFC), ventral striatum and amygdala, which were frequently implicated in reward outcome processing. In these regions of interest, we performed multi-voxel pattern analysis to specifically probe how negative emotion modulates reward outcome processing. In vmPFC, using decoding analysis, we found evidence consistent with the reduced discriminability of multi-variate activity patterns of reward vs no-reward outcomes when signaled by a negative relative to a neutral image, suggesting an emotional modulation of reward processing along the plausible common value/valence dimension. These findings advance our limited understanding of the basic brain mechanisms underlying the influence of negative emotion on consummatory reward processing, with potential implications for mental disorders, particularly anxiety and depression.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
8.00
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信