从不吸烟的肺癌:深入研究流行病学、基因组和免疫景观、预后、治疗和筛查。

IF 4.6 2区 医学 Q1 RESPIRATORY SYSTEM
Lung Pub Date : 2023-12-01 Epub Date: 2023-11-16 DOI:10.1007/s00408-023-00661-3
Ayse Ece Cali Daylan, Emily Miao, Kevin Tang, Grace Chiu, Haiying Cheng
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引用次数: 0

摘要

从不吸烟者肺癌(LCINS)代表了肺部恶性肿瘤中一个不断增长和独特的实体。本综述提供了LCINS的全面概述,包括其流行病学趋势、危险因素、独特的基因组改变、临床结果和正在进行的旨在制定针对这一独特人群的筛查指南的倡议。随着LCINS的不断突出,了解其复杂的基因组景观已成为制定有效治疗策略的关键。此外,根据现行指南,LCINS不符合肺癌筛查的标准。因此,迫切需要探索其异质性,以便制定有利于早期发现的最佳筛查指南。这篇综述强调了详细研究的重要性,以阐明LCINS的多面性,并有可能为这一独特且不断增长的患者群体塑造未来的临床管理和筛查建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening.

Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening.

Lung cancer in never smokers (LCINS) represents a growing and distinct entity within the broader landscape of lung malignancies. This review provides a comprehensive overview of LCINS, encompassing its epidemiologic trends, risk factors, distinct genomic alterations, clinical outcomes and the ongoing initiative aimed at formulating screening guidelines tailored to this unique population. As LCINS continues to gain prominence, understanding its intricate genomic landscape has become pivotal for tailoring effective therapeutic strategies. Moreover, LCINS does not meet the criteria for lung cancer screening as per the current guidelines. Hence, there is an urgent need to explore its heterogeneity in order to devise optimal screening guidelines conducive to early-stage detection. This review underscores the vital importance of detailed research to elucidate the multifaceted nature of LCINS, with the potential to shape future clinical management and screening recommendations for this unique and growing patient cohort.

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来源期刊
Lung
Lung 医学-呼吸系统
CiteScore
9.10
自引率
10.00%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
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