{"title":"PGT-A胚胎染色体非整倍体的评估","authors":"G Shiva Krishna","doi":"10.24321/2278.2044.202324","DOIUrl":null,"url":null,"abstract":"Introduction: Preimplantation genetic testing is a procedure to evaluate genetically normal embryos and take them for embryo transfer. It helps in identifying chromosomal aneuploidies, mosaicism, and euploid embryos.Aim: To assess chromosomal aneuploidy through PGT-A in IVF embryos. Methods: A retrospective study was done from January 2021 to June 2022. 55 blastocysts were assessed for PGT-A through Comparative Genomic Hybridisation (CGH). Results: Among the 55 blastocysts included in the study, 19 embryos showed euploidy and 7 embryos showed multiple aneuploidies. Autosomes were normal but sex chromosomes were abnormal in 3 embryos. Multiple mosaic gain/ loss was reported in 4 embryos. Sex chromosomes abnormality was seen in 8 embryos. Conclusion: 19 embryos showed euploidy. More than half of the embryos showed aneuploidy. Mosaicism seems to be a more common phenomenon in IVF embryos as compared to other kinds of aneuploidy like syndromes, triploidy, monosomy, and other genetic abnormalities. Sex chromosome abnormality was reported in 8 embryos. How to cite this article:Krishna GS, Gupta SK. Assessment of Chromosomal Aneuploidy in PGT-A Embryos. Chettinad Health City Med J. 2023;12(2):28-32. DOI: https://doi.org/10.24321/2278.2044.202324  ","PeriodicalId":276735,"journal":{"name":"Chettinad Health City Medical Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessment of Chromosomal Aneuploidy in PGT-A Embryos\",\"authors\":\"G Shiva Krishna\",\"doi\":\"10.24321/2278.2044.202324\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Preimplantation genetic testing is a procedure to evaluate genetically normal embryos and take them for embryo transfer. It helps in identifying chromosomal aneuploidies, mosaicism, and euploid embryos.Aim: To assess chromosomal aneuploidy through PGT-A in IVF embryos. Methods: A retrospective study was done from January 2021 to June 2022. 55 blastocysts were assessed for PGT-A through Comparative Genomic Hybridisation (CGH). Results: Among the 55 blastocysts included in the study, 19 embryos showed euploidy and 7 embryos showed multiple aneuploidies. Autosomes were normal but sex chromosomes were abnormal in 3 embryos. Multiple mosaic gain/ loss was reported in 4 embryos. Sex chromosomes abnormality was seen in 8 embryos. Conclusion: 19 embryos showed euploidy. More than half of the embryos showed aneuploidy. Mosaicism seems to be a more common phenomenon in IVF embryos as compared to other kinds of aneuploidy like syndromes, triploidy, monosomy, and other genetic abnormalities. Sex chromosome abnormality was reported in 8 embryos. How to cite this article:Krishna GS, Gupta SK. Assessment of Chromosomal Aneuploidy in PGT-A Embryos. Chettinad Health City Med J. 2023;12(2):28-32. DOI: https://doi.org/10.24321/2278.2044.202324  \",\"PeriodicalId\":276735,\"journal\":{\"name\":\"Chettinad Health City Medical Journal\",\"volume\":\"34 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chettinad Health City Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24321/2278.2044.202324\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chettinad Health City Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24321/2278.2044.202324","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Assessment of Chromosomal Aneuploidy in PGT-A Embryos
Introduction: Preimplantation genetic testing is a procedure to evaluate genetically normal embryos and take them for embryo transfer. It helps in identifying chromosomal aneuploidies, mosaicism, and euploid embryos.Aim: To assess chromosomal aneuploidy through PGT-A in IVF embryos. Methods: A retrospective study was done from January 2021 to June 2022. 55 blastocysts were assessed for PGT-A through Comparative Genomic Hybridisation (CGH). Results: Among the 55 blastocysts included in the study, 19 embryos showed euploidy and 7 embryos showed multiple aneuploidies. Autosomes were normal but sex chromosomes were abnormal in 3 embryos. Multiple mosaic gain/ loss was reported in 4 embryos. Sex chromosomes abnormality was seen in 8 embryos. Conclusion: 19 embryos showed euploidy. More than half of the embryos showed aneuploidy. Mosaicism seems to be a more common phenomenon in IVF embryos as compared to other kinds of aneuploidy like syndromes, triploidy, monosomy, and other genetic abnormalities. Sex chromosome abnormality was reported in 8 embryos. How to cite this article:Krishna GS, Gupta SK. Assessment of Chromosomal Aneuploidy in PGT-A Embryos. Chettinad Health City Med J. 2023;12(2):28-32. DOI: https://doi.org/10.24321/2278.2044.202324
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