前列腺癌的分子解剖及其在主动监测和早期干预策略中的意义

Anatomia Pub Date : 2023-10-10 DOI:10.3390/anatomia2040027
Sandy Figiel, Géraldine Cancel-Tassin, Ian G. Mills, Alastair D. Lamb, Gaelle Fromont, Olivier Cussenot
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引用次数: 0

摘要

了解前列腺癌的发生不仅对于确定新的治疗目标,而且对于制定有效的策略来管理无症状的疾病形式至关重要。关于预测前列腺癌的惰性形式缺乏共识,导致治疗开始的不确定性。本综述旨在通过提供前列腺分子解剖学的全面图片,综合现有证据,突出知识差距,并确定未来的方向,加强早期前列腺癌的评估和管理。它为主动监测作为一种替代治疗策略的有效性和通过雄激素受体破坏的特定患者群体的潜在益处提供了证据。总的来说,提高对前列腺癌发生及其分子基础的理解可以为这种常见癌症的量身定制和精确管理方法铺平道路。需要进一步开发和验证基于分子的评估工具。整合基因组,蛋白质组学和表型模型,以及功能方法,可以帮助预测结果。这有助于选择候选人进行主动监测,并针对高风险病例采取有针对性的干预措施,有助于制定更精确的管理战略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular Anatomy of Prostate Cancer and Its Implications in Active Surveillance and Early Intervention Strategies
Understanding prostate carcinogenesis is crucial not only for identifying new treatment targets but also for developing effective strategies to manage the asymptomatic form of the disease. There is a lack of consensus about predicting the indolent form of the disease prostate cancer, leading to uncertainties regarding treatment initiation. This review aims to enhance the assessment and management of early prostate cancer by providing a comprehensive picture of the molecular anatomy of the prostate, synthesising current evidence, highlighting knowledge gaps, and identifying future directions. It presents evidence for the efficacy of active surveillance as an alternative treatment strategy and its potential benefits in specific patient groups through androgen receptor disruption. Overall, an improved understanding of prostate carcinogenesis and its molecular underpinnings can pave the way for tailored and precise management approaches for this common cancer. Further development and validation of molecule-based assessment tools are needed. Integrating genomic, proteomic, and phenotypic models, as well as functional approaches, can help predict outcomes. This facilitates selecting candidates for active surveillance and targeting interventions for higher-risk cases, contributing to more precise management strategies.
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