{"title":"[头孢噻肟及其代谢物去乙酰头孢噻肟对医院感染分离的肠杆菌、葡萄球菌和脆弱拟杆菌的体外活性和相互作用的评价]。","authors":"E Pitzus","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The paper reports a study of the activity of cefotaxime and its metabolite, desacetylcefotaxime, and the association of the two compounds, against 699 strains of enterobacteria, staphylococci and Bacteroides fragilis of hospital origin. The results of the study confirm the good activity of the drug and the less satisfactory activity of its metabolite, which is nevertheless comparable to second generation cephalosporins. The 1:1 association of the two compounds showed synergism in percentages ranging from 3.7% to 15% of strains, and partial synergies of indifference to the remaining strains. Antagonisms were only observed against some M. morgani and H. alvei strains.</p>","PeriodicalId":12704,"journal":{"name":"Giornale italiano di chemioterapia","volume":"36 1-3","pages":"57-64"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[In vitro evaluation of the activity and interactions of cefotaxime and its metabolite desacetylcefotaxime against strains of enterobacteria, staphylococci and Bacteroides fragilis isolated from hospital infections].\",\"authors\":\"E Pitzus\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The paper reports a study of the activity of cefotaxime and its metabolite, desacetylcefotaxime, and the association of the two compounds, against 699 strains of enterobacteria, staphylococci and Bacteroides fragilis of hospital origin. The results of the study confirm the good activity of the drug and the less satisfactory activity of its metabolite, which is nevertheless comparable to second generation cephalosporins. The 1:1 association of the two compounds showed synergism in percentages ranging from 3.7% to 15% of strains, and partial synergies of indifference to the remaining strains. Antagonisms were only observed against some M. morgani and H. alvei strains.</p>\",\"PeriodicalId\":12704,\"journal\":{\"name\":\"Giornale italiano di chemioterapia\",\"volume\":\"36 1-3\",\"pages\":\"57-64\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Giornale italiano di chemioterapia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Giornale italiano di chemioterapia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[In vitro evaluation of the activity and interactions of cefotaxime and its metabolite desacetylcefotaxime against strains of enterobacteria, staphylococci and Bacteroides fragilis isolated from hospital infections].
The paper reports a study of the activity of cefotaxime and its metabolite, desacetylcefotaxime, and the association of the two compounds, against 699 strains of enterobacteria, staphylococci and Bacteroides fragilis of hospital origin. The results of the study confirm the good activity of the drug and the less satisfactory activity of its metabolite, which is nevertheless comparable to second generation cephalosporins. The 1:1 association of the two compounds showed synergism in percentages ranging from 3.7% to 15% of strains, and partial synergies of indifference to the remaining strains. Antagonisms were only observed against some M. morgani and H. alvei strains.
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