((2-(吡咯烷-1-酰基)乙基)亚氨基)甲基萘-2-醇衍生铜(II)和钴(III)配合物的合成、晶体结构和脲酶抑制作用

IF 1.2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Acta Chimica Slovenica Pub Date : 2023-09-20 DOI:10.17344/acsi.2023.8253

Jian Jiang, Peng Liang, Liang Han, Hui Zhang, Zhonglu You

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引用次数: 0

摘要

制备了三种铜(II)和钴(III)配合物[CuL(dca)]n (1)， [CuL(N3)]n(2)和[CoL(N3)2(DMF)](3)，其中L为希夫碱的单阴离子形式((2-(吡咯烷-1-酰基)乙基)亚氨基)甲基)萘-2-醇(HL)， dca为二氰酰胺)，并通过元素分析，IR和UV-Vis光谱以及单晶x射线衍射进行了表征。配合物1和2中的Cu原子呈方锥体配位，配合物3中的Co原子呈八面体配位。配合物1和2对青豆脲酶抑制作用的IC50值分别为0.25±0.14和0.32±0.15 μmol L-1。配合物3对豆豉脲酶的抑制率为37%，活性较弱。

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Synthesis, Crystal Structures and Urease Inhibition of Copper(II) and Cobalt(III) Complexes Derived from (((2-(Pyrrolidin-1-yl)ethyl)imino)methyl)naphthalen-2-ol

Three copper(II) and cobalt(III) complexes, [CuL(dca)]n (1), [CuL(N3)]n (2) and [CoL(N3)2(DMF)] (3), where L is the monoanionic form of the Schiff base (((2-(pyrrolidin-1-yl)ethyl)imino)methyl)naphthalen-2-ol (HL), and dca is dicyanamide, have been prepared and characterized by elemental analyses, IR and UV-Vis spectroscopy, as well as single crystal X-ray diffraction. The Cu atoms in complexes 1 and 2 are in square pyramidal coordination, and the Co atom in complex 3 is in octahedral one. Complexes 1 and 2 inhibit the Jack bean urease with IC50 values of 0.25 ± 0.14 and 0.32 ± 0.15 μmol L–1, respectively. Complex 3 show weak activity on Jack bean urease with percentage inhibition of 37%.

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来源期刊

Acta Chimica Slovenica 化学-化学综合

CiteScore

2.50

自引率

25.00%

发文量

审稿时长

1.0 months

期刊介绍： Is an international, peer-reviewed and Open Access journal. It provides a forum for the publication of original scientific research in all fields of chemistry and closely related areas. Reviews, feature, scientific and technical articles, and short communications are welcome.