Min-kyoung Park, Sae-hee Cheon, Kyung-min Kim, Hye-jin Kim, Min-kyung Lee
{"title":"萝卜硫素和白藜芦醇联合给药对大鼠口腔面部疼痛的控制作用","authors":"Min-kyoung Park, Sae-hee Cheon, Kyung-min Kim, Hye-jin Kim, Min-kyung Lee","doi":"10.33615/jkohs.2023.11.3.114","DOIUrl":null,"url":null,"abstract":"Objectives: This study was designed to confirm the effects of natural products on the control of facial pain.
 Methods: In this study, 5% formalin was injected into the face of the experimental animals to induce pain behavioral responses, and sulforaphane 15 μg or 150 μg/50 μl and resveratrol 20 μg or 200 μg/50 μl were pre-treated to confirm the pain control effects.
 Results: The two drugs showed pain-modifying effects in a concentration-dependent manner. In addition, a significant analgesic effect was confirmed when the two drugs were co-administered at low concentrations.
 Conclusions: Therefore, through this experiment, sulforaphane and resveratrol can be effective therapeutic agents for controlling orofacial pain.","PeriodicalId":496938,"journal":{"name":"한국구강보건과학회지","volume":"42 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Combined Administration of Sulforaphane and Resveratrol on Orofacial Pain Control in Rats\",\"authors\":\"Min-kyoung Park, Sae-hee Cheon, Kyung-min Kim, Hye-jin Kim, Min-kyung Lee\",\"doi\":\"10.33615/jkohs.2023.11.3.114\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: This study was designed to confirm the effects of natural products on the control of facial pain.
 Methods: In this study, 5% formalin was injected into the face of the experimental animals to induce pain behavioral responses, and sulforaphane 15 μg or 150 μg/50 μl and resveratrol 20 μg or 200 μg/50 μl were pre-treated to confirm the pain control effects.
 Results: The two drugs showed pain-modifying effects in a concentration-dependent manner. In addition, a significant analgesic effect was confirmed when the two drugs were co-administered at low concentrations.
 Conclusions: Therefore, through this experiment, sulforaphane and resveratrol can be effective therapeutic agents for controlling orofacial pain.\",\"PeriodicalId\":496938,\"journal\":{\"name\":\"한국구강보건과학회지\",\"volume\":\"42 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"한국구강보건과학회지\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33615/jkohs.2023.11.3.114\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"한국구강보건과학회지","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33615/jkohs.2023.11.3.114","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of Combined Administration of Sulforaphane and Resveratrol on Orofacial Pain Control in Rats
Objectives: This study was designed to confirm the effects of natural products on the control of facial pain.
Methods: In this study, 5% formalin was injected into the face of the experimental animals to induce pain behavioral responses, and sulforaphane 15 μg or 150 μg/50 μl and resveratrol 20 μg or 200 μg/50 μl were pre-treated to confirm the pain control effects.
Results: The two drugs showed pain-modifying effects in a concentration-dependent manner. In addition, a significant analgesic effect was confirmed when the two drugs were co-administered at low concentrations.
Conclusions: Therefore, through this experiment, sulforaphane and resveratrol can be effective therapeutic agents for controlling orofacial pain.
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