组胺通过小鼠特定肠道菌群调节脑源性神经营养因子(BDNF)分解代谢

IF 0.7 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY
Qiaoqiao Luo, Ruoyu Shi, Yutong Liu, Libo Huang, Wei Chen, Chengtao Wang
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引用次数: 0

摘要

黄酒通常会使人过度中毒。虽然主要成分,包括β-苯乙醇、异戊醇、组胺和苯乙胺与中毒有关,但其潜在机制尚不清楚。因此,本研究分析了口服这些成分,特别是组胺的作用,并发现了哪些成分在小鼠血清和大脑中引起氧化应激和炎症细胞因子反应。脂多糖水平升高,肠道菌群重组。此外,还研究了脑源性神经营养因子的分解代谢途径。相关性分析显示肠道菌群变化与神经递质失衡之间可能存在相关性。根据研究结果,组胺可能改变肠道菌群组成,影响炎症性LPS积累,调节肠-脑轴,从而导致大脑氧化应激、炎症反应和神经递质失衡的增加。本研究为进一步研究黄酒的作用提供了基础,并提高了我们对治疗和预防相关炎症疾病的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histamine-regulated brain-derived neurotrophic factor (BDNF) catabolism by specific gut microbiota in mice
Huangjiu usually causes excessive intoxication. Although the primary components, including β-benzyl ethanol, isopentanol, histamine, and phenethylamine are linked to intoxication, the underlying mechanism remains obscure. The present work thus analysed the effects of oral treatment of these components, particularly histamine, and discovered which of these components induced oxidative stress and inflammatory cytokine responses in mice serum and cerebrum. Lipopolysaccharide levels were elevated, and the gut microbiota was recomposed. Additionally, the catabolic pathway of the brain-derived neurotrophic factor was investigated. The correlation analysis revealed a possible correlation between gut microbiota changes and neurotransmitter imbalance. Based on the findings, histamine might alter the gut microbiota composition, affect the inflammatory LPS accumulation, and modulate the gut-brain axis, thus leading to an increase in oxidative stress, inflammatory response, and neurotransmitter imbalance in the brain. The present work provided a baseline for future research into the effects of Huangjiu, and enhanced our understanding of treating and preventing associated inflammatory diseases.
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来源期刊
international food research journal
international food research journal Agricultural and Biological Sciences-Food Science
CiteScore
1.40
自引率
0.00%
发文量
75
期刊介绍: The International Food Research Journal (IFRJ) publishes papers in English, six (6) issues a year with the coverage of: Food Science and Technology Nutrition and Dietetics Agriculture, multidisciplinary Chemistry, multidisciplinary The scope of the Journal includes: Food Science, Food Technology and Food Biotechnology Product Development and Sensory Evaluation Food Habits, Nutrition, and Health Food Safety and Quality Food Chemistry, Food Microbiology, Food Analysis and Testing Food Engineering Food Packaging Food Waste Management Food Entrepreneur Food Regulatory Post-Harvest Food Management Food Supply Chain Management Halal Food and Management
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