基于马拉维Zomba中心医院1A、2A和5A方案记录的一线抗逆转录病毒药物对HIV患者副作用的回顾性研究

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

African Health Sciences Pub Date : 2023-10-11 DOI:10.4314/ahs.v23i3.54

Ruth Sindie, Elias Mwakilama, Pachalo Chizala, Jimmy Namangale

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引用次数: 0

摘要

艾滋病是一种不治之症，在非洲很常见。CD4细胞计数低于240的艾滋病毒/艾滋病患者需要服用延长生命的抗逆转录病毒药物。抗逆转录病毒药物对一些患者有严重的副作用，可以通过治疗这些患者或将患者的药物转换为没有或不那么严重副作用的药物来解决。然而，在这样做之前，更多地了解导致副作用的情况是至关重要的。根据医院数据记录，我们使用统计分析将1A、2A和5A治疗方案的副作用与患者的社会和人口统计学特征联系起来。对患者的主卡(2011-2014)进行回顾性审查，以评估与不同抗逆转录病毒治疗方案相关的不良反应。901例出现不良反应的患者中，31 ~ 40岁女性占65.37%，男性占34.63%。相比之下，1A方案的副作用大于2A和5A方案。年龄、性别和职业与方案症状显著相关(p<0.05)。与男性不同，女性有以下额外的副作用;与脂肪营养不良相比，咳嗽、周围神经病变和腿痛。我们的研究结果显示，与脂肪营养不良相比，老年人(50岁以上)出现皮疹等症状的可能性较小(RRR=0.973)。此外，咳嗽的概率(0.0021,p<0.05)或皮疹(0.0021,p / lt;0.05)，副作用随着年龄的增长而降低，性别和体重相同。周围神经病变的概率(0.0042,p<0.01)，但随年龄增长而增加。了解艾滋病毒患者的社会人口特征和患者的治疗方案副作用可用于适当管理严重的抗逆转录病毒药物副作用。考虑到抗逆转录病毒治疗方案中导致特定副作用的化学物质的治疗考虑，可以针对具有相容的社会人口特征的患者。关键词:艾滋病;抗逆转录病毒治疗方案;症状;副作用;socio-demographics;多项逻辑回归。

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A retrospective study on side effects of first-line antiretroviral drugs on HIV patients based on 1A, 2A, and 5A regimen records at Zomba Central Hospital, Malawi

AIDS is an incurable disease that is common in Africa. Patients with HIV/AIDS having a CD4 count of less than 240 are put on life prolonging ARV drugs. The ARVs have serious side effects on some patients which may be handled by treating them or switching patient’s drug to one with no or less serious side effects. However, before doing this, more understanding of the circumstances that lead to a side effect is vital. We use statistical analyses to link side effects of 1A, 2A, and 5A treatment regimens to the patient’s social and demographic characteristics based on hospital data records. A retrospective review of patients’ master cards (2011-2014) was done to assess adverse effects associated with different ARV regimens. Out of the 901 patients that showed side effects, 65.37% were females aged 31-40 and 34.63% were males. Comparatively, 1A regimen showed more side effects than 2A and 5A regimens. Age, gender and occupation correlated significantly with regimen symptoms (p< 0.05). Unlike men, women had the following extra side effects; cough, peripheral neuropathy and leg pains as compared to lipodystrophy. Our results show that old people (50years+) are less likely to get skin rash and other symptoms compared to lipodystrophy (RRR=0.973). Further, the probability of either having cough (0.0021, p< 0.05), or skin rash (0.0021, p< 0.05), as a side effect, on average, decreases as age increases with the same sex and weight. The probability of having peripheral neuropathy (0.0042, p< 0.01), however, increases with age. Knowledge of HIV patient’s socio-demographics and the patient’s regimen side effects can be utilised to appropriately manage severe ARV side effects. A therapy consideration that takes into account chemicals in ARV regimen responsible for specific side effects can be directed to patients with compatible socio-demographic characteristics. Keywords: HIV/AIDS; ARV regimens; symptoms; side effects; socio-demographics; multinomial logistic regression.

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来源期刊

African Health Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

179

审稿时长

>12 weeks

期刊介绍： The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.